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Research progress on N-Methyladenosine modification in angiogenesis, vasculogenic mimicry, and therapeutic implications in breast cancer.
Prog Biophys Mol Biol
December 2024
Translational Medical Innovation Center, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou City, Jiangsu, 215600, China. Electronic address:
N-methyladenosine (mA) modification is the most common epitranscriptomic modification in eukaryotic RNA and has garnered extensive attention in the context of breast cancer research. The mA modification significantly impacts tumorigenesis and tumor progression by regulating RNA stability, splicing, translation, and degradation. In this review we summarize recent advances in understanding the roles of mA modification in the mechanisms underlying angiogenesis and vasculogenic mimicry in breast cancer.
View Article and Find Full Text PDFAngiogenesis refers to the process of forming a new network of blood vessels from existing ones through the migration, proliferation, and differentiation of endothelial cells. This process is crucial for the growth and spread of solid tumors, particularly once the tumor volume exceeds 2 mm, as the newly formed vascular network provides essential oxygen, nutrients, and growth factors to the tumor. Anti-angiogenesis therapy has become one of the commonly used targeted treatments for cancer in clinical practice.
View Article and Find Full Text PDFEmerging Paradigms in Cancer Metastasis: Ghost Mitochondria, Vasculogenic Mimicry, and Polyploid Giant Cancer Cells.
Cancers (Basel)
October 2024
Department of Clinical and Experimental Pathology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.
The capacity of cancer cells to migrate from a primary tumor, disseminate throughout the body, and eventually establish secondary tumors is a fundamental aspect of metastasis. A detailed understanding of the cellular and molecular mechanisms underpinning this multifaceted process would facilitate the rational development of therapies aimed at treating metastatic disease. Although various hypotheses and models have been proposed, no single concept fully explains the mechanism of metastasis or integrates all observations and experimental findings.
View Article and Find Full Text PDFIdentification of new subtypes of breast cancer based on vasculogenic mimicry related genes and a new model for predicting the prognosis of breast cancer.
Heliyon
September 2024
Cancer Center, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, China.
Article Synopsis
- Breast cancer is a serious health threat for women and the presence of vasculogenic mimicry (VM) is linked to poorer outcomes in patients.
- The study used various databases to explore the role of VM-related genes in breast cancer, analyzing aspects like gene expression, mutation status, and immune cell infiltration.
- By clustering patients based on VM characteristics, the research identified two groups, where one group with greater immune activity showed better survival rates, and three important prognostic genes were highlighted for future treatment strategies.
Human Chorionic Membrane-derived Tunable Hydrogels for Vascular Tissue Engineering Strategies.
Adv Healthc Mater
January 2025
Department of Chemistry, CICECO, University of Aveiro, Campus Universitário de Santiago, Aveiro, 3810-193, Portugal.
One of the foremost targets in the advancement of biomaterials to engineer vascularized tissues is not only to replicate the composition of the intended tissue but also to create thicker structures incorporating a vascular network for adequate nutrients and oxygen supply. For the first time, to the best of current knowledge, a clinically relevant biomaterial is developed, demonstrating that hydrogels made from the human decellularized extracellular matrix can exhibit robust mechanical properties (in the kPa range) and angiogenic capabilities simultaneously. These properties enable the culture and organization of human umbilical vein endothelial cells into tubular structures, maintaining their integrity for 14 days in vitro without the need for additional polymers or angiogenesis-related factors.
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