AI Article Synopsis
- Inorganic polyphosphate, found in osteoblasts, is believed to play a role in bone health and the study aimed to explore its effects on periodontitis.
- A randomized double-blind study involved 33 patients receiving local irrigation with inorganic polyphosphate, followed by standard dental cleaning a week later.
- Results showed no major differences between the treatment and control groups, but older patients treated with polyphosphate showed improvements in gum health and some evidence of bone regeneration.
Article Abstract
Aim: Inorganic polyphosphate exists as chains of phosphate molecules and is distributed in osteoblasts, and regulates osteoblastic cell differentiation and bone matrix calcification. The purpose of this study was to clarify the effects of inorganic polyphosphate on periodontitis.
Material And Methods: Subgingival local irrigation with inorganic polyphosphate was studied in a randomised double-blind study of 33 patients with periodontitis. Scaling and root planing were performed 1 week after the initial examination.
Results: No significant differences between the inorganic polyphosphate group and control were detected in each item except IL-1beta. Patients in whom both the bleeding on probing and gingival index at 1 week had improved were significantly older in the inorganic polyphosphate group than in the control group (p < 0.05). Bone regeneration was seen in one case of the inorganic polyphosphate group.
Conclusions: Inorganic polyphosphate was useful in the treatment of periodontitis in the elderly, indicating a probable effect of anti-ageing, with similar bone regenerations occurring in both groups.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1741-2358.2007.00185.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Structural Insights into Broad-Range Polyphosphate Kinase 2‑II Enzymes Applicable for Pyrimidine Nucleoside Diphosphate Synthesis.
Chembiochem
January 2025
University of Freiburg: Albert-Ludwigs-Universitat Freiburg, Institute of Pharmaceutical Sciences, Albertstr. 25, 79104, Freiburg, GERMANY.
Polyphosphate kinases (PPK) play crucial roles in various biological processes, including energy storage and stress responses, through their interaction with inorganic polyphosphate (polyP) and the intracellular nucleotide pool. Members of the PPK family 2 (PPK2s) catalyse polyP‑consuming phosphorylation of nucleotides. In this study, we characterised two PPK2 enzymes from Bacillus cereus (BcPPK2) and Lysinibacillus fusiformis (LfPPK2) to investigate their substrate specificity and potential for selective nucleotide synthesis.
View Article and Find Full Text PDFA framework for understanding and investigating polyphosphate-protein interactions.
Biochem Soc Trans
January 2025
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Many prokaryotic and eukaryotic cells store inorganic phosphate in the form of polymers called polyphosphate (polyP). There has been an explosion of interest in polyP over the past decade, in part due to newly suggested roles related to diverse aspects of human health. The physical interaction of polyP chains with specific proteins has been proposed to regulate cellular homeostasis and modulate signaling pathways in response to environmental changes.
View Article and Find Full Text PDFDifferential effects of endo- and exopolyphosphatase expression on the induction of the mitochondrial permeability transition pore.
Biochim Biophys Acta Biomembr
January 2025
Department of Molecular Pathobiology, New York University, New York, NY, USA. Electronic address:
Inorganic polyphosphate (polyP) is a polymer that consists of a series of orthophosphates connected by high-energy phosphoanhydride bonds, like those found in ATP. In mammalian mitochondria, polyP has been linked to the activation of the mitochondrial permeability transition pore (mPTP). However, the details of this process are not completely understood.
View Article and Find Full Text PDFLignosulfonate-based deflocculant and its derivatives for water-based drilling mud: A review.
Int J Biol Macromol
January 2025
Department of Petroleum and Gas Engineering Technology, Federal Polytechnic of Oil and Gas, Bonny-island, PMB 5027, Rivers State, Nigeria.
Chromium-based lignosulfonate (CrLS) deflocculants that are commonly used in water-based drilling muds (WBDMs) to deflocculate bentonites under high temperature (HT), high-pressure (HP), and high-salinity (HS) oil well drilling conditions have been found to contain heavy metals such as chromium, which is toxic and degrades rapidly. However, different ways of addressing this issue have been proffered, including the use of natural polymers such as starch, cellulose, or anionic inorganic agents such as sodium polyphosphates with little or no impact. Other lignosulfonate (LS)-based deflocculants, like sodium-based LS and bio-based LS, have shown a number of benefits, such as being better for the environment, more soluble and evenly distributed in WBDMs, more resistant to salt contamination, easily biodegradable, safe, and able to go through different chemical changes.
View Article and Find Full Text PDFMulti-omics reveals mechanism of hydroxylamine-enhanced ultimate nitrogen removal in pilot-scale anaerobic/aerobic/anoxic system.
Water Res
January 2025
National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology, Engineering Research Center of Beijing, Beijing University of Technology, Beijing 100124, PR China. Electronic address:
Hydroxylamine (HA) dosing is an effective strategy for promoting partial nitrification (PN); however, its impact on endogenous denitrification remains underexplored. In this study, long-term continuous HA dosing (1.4 mg/L) was introduced for over 110 days in a pilot-scale anaerobic/aerobic/anoxic (AOA) system treating municipal wastewater (66.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!