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Factor analysis of lifetime psychopathology and its brain morphometric and genetic correlates in a transdiagnostic sample.
Transl Psychiatry
June 2024
Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Article Synopsis
- - The study explores the connections between dimensional psychopathological syndromes and brain structure/function in patients with Major Depressive Disorder, Bipolar Disorder, Schizoaffective Disorder, and Schizophrenia, analyzing data from 1,038 individuals.
- - Researchers identified three main psychopathological factors—paranoid-hallucinatory syndrome, mania, and depression—and found significant brain volume and cortical thickness differences linked to the paranoid-hallucinatory syndrome.
- - Genome-wide association studies revealed significant genetic associations for mania and depression, suggesting a need for more dimensional perspectives in psychiatric classifications to improve understanding and treatment.
Reshaping the diagnostic borders: Historical analysis of the diagnostic changes following the introduction of the schizophrenia concept.
Schizophr Res
December 2023
University Hospital Strasbourg, Psychiatry Department, France; University of Strasbourg, INSERM 1114, FMTS, France.
Background: Although the concept of schizophrenia is still widely presented as having replaced that of dementia praecox, studies have shown that the former was broader than the latter, resulting in a more complex diagnostic redistribution. However, this is poorly documented by quantitative approaches.
Aims: We sought to test the hypothesis that the use of the concept of schizophrenia had caused a diagnostic redistribution and to quantify it.
[Recent developments in the modeling and psychological management of persecutory ideation].
Encephale
February 2024
Départment de psychologie, université de Grenoble-Alpes, université Savoie-Mont-Blanc, LIP/PC2S, Grenoble, France; Département de psychologie, institut universitaire de France, Paris, France.
Persecutory ideas are a major clinical problem and are associated with impaired functioning, reduced compliance with medication and increased risk of hospitalization. Persecutory ideation is defined as the false conviction that others are threatening or conspiring against one. Although persecutory delusions are mainly described and experienced in schizophrenia spectrum disorders, they also occur in other neurological and psychiatric diagnoses including Alzheimer disease, epilepsy, depression, mania, dementia and post-traumatic stress disorder.
View Article and Find Full Text PDFThe Immunoseasonal Theory of Psychiatric Disorders.
J Clin Med
July 2023
Department of Psychiatry, Medical University of Białystok, Wołodyjowskiego 2, 15-272 Białystok, Poland.
Although the influence of the weather on the well-being and mental health of psychiatric patients has been widely seen, the relationships between various seasonal weather factors and depressive, manic, anxiety, and psychotic states have not been systematized in the literature. The current article describes the seasonal changes in weather-related immune responses and their impact on the development of episodes of depression, mania, psychosis, and anxiety, highlighting the T-helper 1 (Th1) and Th2 immune balance as their potential trigger. In autumn-winter depression, the hyperactivation of the Th1 system, possibly by microbial/airborne pathogens, may lead to the inflammatory inhibition of prefrontal activity and the subcortical centers responsible for mood, drive, and motivation.
View Article and Find Full Text PDFTracing the Roots of Dementia Praecox: Charles Lasègue and his 1852 Essay "Du Délire De Persécutions" (On Persecutory Delusions).
Schizophr Bull
September 2023
Psychiatry Department, Virginia Commonwealth University, Richmond, VA 980126, USA.
While the evolution of our modern concepts of mania and melancholia over the 19th century is relatively well-understood, no such clear narrative exists for the nonaffective psychotic syndromes that culminated in Kraepelin's concept of dementia praecox in 1899. These narratives were relatively distinct in Germany and France. An important milestone in the French literature is the 1852 essay by the alienist and polymath Charles Lasègue which contained the first detailed modern description of a persecutory delusional syndrome.
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