AI Article Synopsis
- Pure poly(lactide-co-glycolide) and polystyrene surfaces are poor at promoting cell adhesion due to their hydrophobic properties and low surface energy.
- The use of radio-frequency, low-pressure air plasma significantly improves the wettability of these surfaces, evidenced by a decrease in contact angles.
- Plasma treatment alters the surface composition and zeta-potential, indicating a higher presence of functional groups and a shift towards a less acidic character, enhancing the surface properties of large porous 3D scaffolds.
Article Abstract
Pure poly(lactide-co-glycolide) and polystyrene surfaces are not very suitable to support cell adhesion/spreading owing to their hydrophobic nature and low surface energy. The interior surfaces of large porous 3D scaffolds were modified and activated using radio-frequency, low-pressure air plasma. An increase in the wettability of the surface was observed after exposure to air plasma, as indicated by the decrease in the contact angles of the wet porous system. The surface composition of the plasma-treated polymers was studied using X-ray photoelectron spectroscopy. pH-dependent zeta-potential measurements confirm the presence of an increased number of functional groups. However, the plasma-treated surfaces have a less acidic character than the original polymer surfaces as seen by a shift in their isoelectric point. Zeta-potential, as well as contact angle measurements, on 3D scaffolds confirm that plasma treatment is a useful tool to modify the surface properties throughout the interior of large scaffolds.
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| http://dx.doi.org/10.1002/jbm.a.31731 | DOI Listing |
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