As much as 105 mW of single-frequency output at 1342 nm was obtained from a diode-laser-pumped Nd:YVO(4) microchip laser. An intracavity frequency-doubled device generated 10 mW of single-frequency red radiation.
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http://dx.doi.org/10.1364/ol.22.001781 | DOI Listing |
Acta Pharm Sin B
December 2024
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Macrophage-mediated inflammation plays a pivotal role in cardiovascular disease pathogenesis. However, current cell-based models lack a comprehensive understanding of crosstalk between macrophages and cardiomyocytes, hindering the discovery of effective therapeutic interventions. Here, a microfluidic model has been developed to facilitate the coculture of macrophages and cardiomyocytes, allowing for mapping key signaling pathways and screening potential therapeutic agents against inflammation-induced dynamic myocardial injury.
View Article and Find Full Text PDFPolymers (Basel)
December 2024
Department of Physical and Colloid Chemistry, Kazan National Research Technological University, 420015 Kazan, Russia.
Microfluidics provides cutting-edge technological advancements for the in-channel manipulation and analysis of dissolved macromolecular species. The intrinsic potential of microfluidic devices to control key characteristics of polymer macromolecules such as their size distribution requires unleashing its full capacity. This work proposes a combined approach to analyzing the microscale behavior of polymer solutions and modifying their properties.
View Article and Find Full Text PDFMicromachines (Basel)
November 2024
Department of Electrical Engineering, TUM School of Computation, Information and Technology, Technical University of Munich, 80333 Munich, Germany.
Despite major advances in the field of actuator technology for microsystems, miniaturized microfluidic actuation systems for mobile devices are still not common in the market. We present a micropump concept and an associated mass flow sensor design, which, in combination, have the potential to form the basis for an integrated microfluidic development platform for microfluidic systems in general and microdosing systems in particular. The micropump combines the use of active valves with an electrostatic drive principle for the pump membrane and the valves, respectively.
View Article and Find Full Text PDFBiomolecules
December 2024
Department of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jablonna, Poland.
'Organ-on-a-chip' technology is a promising and rapidly evolving model in biological research. This innovative microfluidic cell culture device was created using a microchip with continuously perfused chambers, populated by living cells arranged to replicate physiological processes at the tissue and organ levels. By consolidating multicellular structures, tissue-tissue interfaces, and physicochemical microenvironments, these microchips can replicate key organ functions.
View Article and Find Full Text PDFExpert Opin Drug Deliv
January 2025
Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skoltech, Moscow, Russia.
Introduction: The pursuit of linear dosage in pharmacy is essential for achieving consistent therapeutic release and enhancing patient compliance. This review provides a comprehensive summary of zero-order drug delivery systems, with a particular focus on reservoir-based systems emanated from different microfabrication technologies.
Areas Covered: The consideration of recent advances in drug delivery systems is given to encompass the key areas including the importance of achieving a constant drug release rate for therapeutic applications.
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