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Advances in diagnostic assays for infection in adults.
Front Cell Infect Microbiol
December 2024
Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China.
() was a gram-positive anaerobic in the gut, exhibiting clinical manifestations ranging from mild diarrhoea to fatal pseudomembranous colitis. infection (CDI) remains a serious public health problem and accounted for an estimated 360,075 cases in the United States in 2021. It has attracted the utmost attention of the world health organization (WHO).
View Article and Find Full Text PDFRefractory Chronic Diffuse Granular Myringitis with Medial Meatal Stenosis.
J Int Adv Otol
September 2024
Department of Otorhinolaryngology, Hospital Raja Permaisuri Bainun, Ipoh, Perak, Malaysia.
Article Synopsis
- - Granular myringitis is a persistent inflammation of the eardrum that doesn't affect the middle ear, and there isn’t a standard treatment for it.
- - A 60-year-old woman with persistent ear discharge and hearing loss was initially treated with antibiotics but showed no improvement, leading to a decision for surgery due to complications and impact on her life.
- - Surgical treatment involved removing granulation tissue and improving the ear canal, resulting in symptom resolution and a better quality of life, indicating the approach's potential for chronic cases, though more research is needed on long-term effects.
[Clostridioides difficile infections: Update and therapeutic guidelines].
Geriatr Psychol Neuropsychiatr Vieil
October 2024
CHU de Grenoble-Alpes, Président du Collège National des Enseignants de Gériatrie, France.
Article Synopsis
- * Complications from CDI, such as pseudomembranous colitis and toxic megacolon, require prompt diagnosis through clinical evaluation, microbiological tests, and potentially imaging studies.
- * Treatment typically involves halting harmful antibiotics and using specific antimicrobial therapies, with options like fidaxomicin, oral vancomycin, and fecal microbiota transplantation for recurrent cases.
and Gut Microbiota: From Colonization to Infection and Treatment.
Pathogens
July 2024
Department of Infectious Diseases, Istituto Superiore di Sanità, 00161 Roma, Italy.
Article Synopsis
- Clostridioides difficile (CD) is the leading cause of antibiotic-associated diarrhea (AAD) in developed countries, with both infected and asymptomatic individuals serving as key transmission sources.
- CD infection (CDI) can cause symptoms ranging from mild diarrhea to severe conditions like pseudomembranous colitis, and the prevalence of severe CDI cases has increased in recent years, partly due to new, more virulent strains.
- The relationship between CDI and the gut microbiota is critical, as changes in the microbiota can influence whether CD acts as a colonizer or an invader; restoring a healthy gut microbiota, potentially through interventions like fecal microbiota transplantation (FMT), is viewed as a promising strategy for preventing and
From Hemorrhage to Diarrhea: The Comprehensive Clinical Journey of a Patient With Pseudomembranous Colitis.
Cureus
July 2024
General Medicine, Saveetha Medical College and Hospital, Chennai, IND.
Article Synopsis
- Pseudomembranous colitis (PC) is an inflammation of the colon mainly caused by Clostridium difficile, often triggered by antibiotic use, as seen in a case involving a 48-year-old man with severe health issues who presented with acute weakness and later developed PC during hospitalization.* -
- The patient's condition deteriorated due to complications like ventilator-associated pneumonia from multi-drug resistant bacteria, but he successfully transitioned off mechanical ventilation before facing severe diarrhea and abdominal pain linked to PC, confirmed by stool tests and imaging.* -
- Despite an initial treatment plan including vancomycin and metronidazole, he experienced a relapse of PC, which was confirmed through colonoscopy; this case underscores the need
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