Isolated B-cell lymphoproliferative disorder at the dura mater with B-cell chronic lymphocytic leukemia immunophenotype.

Clin Lymphoma Myeloma

Department of Hematology, Oncology and Transfusion Medicine, Charité Campus Benjamin Franklin, Berlin, Germany.

Published: November 2007

AI Article Synopsis

  • Lymphoma affecting the dura mater is rare and primarily linked to extranodal marginal zone lymphoma of MALT type.
  • A case is presented involving a patient with a meningeal tumor identified as a B-cell lymphoproliferative disorder resembling chronic lymphocytic leukemia.
  • The detection of trisomy 3 in the patient's bone marrow suggests that CD5(+) MALT lymphoma is a critical consideration, although it's not previously documented in dural lymphoma.

Article Abstract

Lymphoma manifestations of the dura mater are extremely rare and have mostly been attributed to extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) type. We report a patient with an isolated meningeal tumor, identified as a B-cell lymphoproliferative disorder with typical B-cell chronic lymphocytic leukemia immunophenotype. Because of the subclinical detection of trisomy 3 in the bone marrow by cytogenetic analysis and interphase fluorescence in situ hybridization, CD5(+) MALT is an important differential diagnosis; however, to our knowledge, this entity has never been reported in the context of dural lymphoma.

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http://dx.doi.org/10.3816/clm.2007.n.047DOI Listing

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