Syringomatous adenoma (SA) of the nipple is a rare tumor first described by Rosen in 1983. It is histologically similar to skin adnexal tumors in other parts of the body. It has been reported under several names including low-grade adenosquamous carcinoma, SA of the nipple, and infiltrating SA of the nipple. Clinical examination and mammographic evidence yield high suspicion for carcinoma and often these lesions are misdiagnosed. Because the lesion involves the nipple, surgical treatment has ranged from local excision to mastectomy. There are 31 cases reported in the English literature, and although they all recommend complete excision, none describe reconstructive efforts. This case report describes a case of SA of the nipple presenting as a chronic abscess. We discuss the surgical treatment including reconstruction after central mound resection as well as pathological findings.
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http://dx.doi.org/10.1111/j.1524-4741.2007.00527.x | DOI Listing |
Hum Pathol
August 2024
Department of Pathology, Koç University Hospital, Istanbul, Turkey; Koç University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey. Electronic address:
A fusion between tubulin polymerization-promoting protein (TPPP), a regulatory cytoskeletal gene, and the chromatin remodeling factor, bromodomain-containing protein 9 (BRD9), TPPP-BRD9 fusion has been found in rare cancer cases, including lung and gallbladder cancers (GBC). In this study, we investigated the histopathological features of 16 GBCs previously shown by RNA sequencing to harbor the TPPP-BRD9 fusion. Findings in the fusion-positive GBCs were compared with 645 GBC cases from the authors' database.
View Article and Find Full Text PDFPan Afr Med J
July 2024
Obstetrics and Gynecology, Oncocenter, Teresina (PI), Brazil.
Radiographics
April 2024
From the Departments of Breast Imaging (M.S.G., E.M.A., M.M.K., M.M.P., F.P., E.S.N., T.W.M., B.E.A.), Pathology-Anatomical (Q.D.), and Breast Surgical Oncology (T.W.M.), The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1350, Houston, TX 77030.
Adv Anat Pathol
November 2023
Division of Pathology, Department of Translation Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Because of the unique anatomic structure of the nipple, a few specific breast lesions occur only at this site. Large lactiferous sinuses may be involved by inflammatory conditions such as squamous metaplasia of lactiferous ducts and ductal ectasia or be the site of uncommon superficial epithelial neoplasms such as nipple adenoma or syringomatous tumor of the nipple. Paget disease of the nipple may be secondary to intraepidermal extension of ductal carcinoma in situ in the underlying lactiferous ducts or develop from malignant transformation of Toker cells.
View Article and Find Full Text PDFClin Case Rep
June 2023
Sparrow Health System Lansing Michigan USA.
Key Clinical Message: SAN should be considered in the setting of nipple discharge or morphology changes with typical histological findings. There are limited published cases of SAN, and workup of this pathology is still not clear to date.
Abstract: Syringomatous adenoma of the nipple (SAN) is known to be a rare benign breast neoplasm.
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