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The impact of bleaching using 15% carbamide peroxide on surface properties of CAD-CAM composite structures.
Sci Rep
January 2025
Division of Dentistry, School of Medical Sciences, The University of Manchester, Manchester, M13 9PL, UK.
This study aims to evaluate the effects of the home bleaching method on the surface microhardness and surface roughness of both polished and unpolished CAD-CAM resin composite materials. A polymer-infiltrated ceramic network (PICN) block, Enamic (VE), along with four resin composite blocks (RCB) (Grandio [GN], Lava™ Ultimate [LV], BRILLIANT Crios [B], and Cerasmart [CS]), were prepared to dimensions of 14 mm × 12 mm × 2 mm and were categorized into unpolished and polished groups (n = 4). Microhardness measurements were conducted using a Vickers microhardness tester (300 gf load for 20 s) at various time points: before home bleaching, after home bleaching with 15% Opalescence for 8 h and for 56 h, 24 h after bleaching, and one month after bleaching.
View Article and Find Full Text PDFInhibition of P2X7 receptor mitigates atrial fibrillation susceptibility in isoproterenol-induced rats.
Biochem Biophys Res Commun
January 2025
Department of Cardiology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, PR China. Electronic address:
Background: Atrial fibrillation (AF) is a common cardiac arrhythmia that is characterized by atrial electrical remodeling. The P2X7 receptor (P2X7R), an ATP-gated ion channel, has been implicated in cardiovascular pathologies; however, its role in atrial electrical remodeling remains unclear. This study investigated whether inhibition of P2X7R could mitigate isoproterenol (ISO)-induced atrial electrical remodeling in rats and explored the underlying mechanisms.
View Article and Find Full Text PDFThree-dimensional structure of entire hydrated murine hearts at histological resolution.
Sci Rep
January 2025
Institute for X-ray Physics, Georg-August University Göttingen, Friedrich-Hund-Platz 1, 37077, Göttingen, Germany.
Imaging the entire cardiomyocyte network in entire small animal hearts at single cell resolution is a formidable challenge. Optical microscopy provides sufficient contrast and resolution in 2d, however fails to deliver non-destructive 3d reconstructions with isotropic resolution. It requires several invasive preparation steps, which introduce structural artefacts, namely dehydration, physical slicing and staining, or for the case of light sheet microscopy also clearing of the tissue.
View Article and Find Full Text PDFEnhanced Circularly Polarized Green Luminescence Metrics from New Enantiopure Binary -Pyrazolonate-Tb Complexes.
Molecules
December 2024
Xi'an Key Laboratory of Advanced Photo-Electronics Materials and Energy Conversion Device, Technological Institute of Materials & Energy Science (TIMES), Xijing University, Xi'an 710123, China.
Achieving superior circularly polarized luminescence brightness () is an important subject and continuous challenge for chiroptical materials. Herein, by applying a binary molecular design for the synthesis of chiral organo-Tb molecules, a novel pair of mononuclear chiral -pyrazolate-Tb enantiomers, [Tb(PMIP)(,-Ph-PyBox)] () and [Tb(PMIP)(,-Ph-PyBox)] (), have been synthesized and characterized. The three 1-phenyl-3-methyl-4-(isobutyryl)-5-pyrazolone () ligands play the role of efficient luminescence sensitizers and strong light-harvesting antennas, while the enantiopure 2,6-bis(4-phenyl-2-oxazolin-2-yl) pyridine ligand (/) is employed as the strong point-chiral inducer.
View Article and Find Full Text PDFPharmacokinetics, pharmacodynamics and bioavailability of dexmedetomidine nasal spray in healthy Chinese adults: A phase I clinical trial.
Front Pharmacol
November 2024
Phase I Clinical Trial Center, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Background: Intranasal administration is a convenient route for drug delivery that can be applied for procedural sedation. However, there is currently limited exploration into fixed dosing regimens. This study was to investigate the pharmacokinetics (PK), pharmacodynamics (PD), bioavailability (BA) and safety of dexmedetomidine after fixed doses of intranasal and intravenous administration in healthy male and female subjects.
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