Lamotrigine-induced neutropenia in a woman with schizoaffective disorder.

Prim Care Companion J Clin Psychiatry

Mental Health and Behavioral Sciences Department, Omaha Veterans Affairs Medical Center.

Published: July 2011

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2139934PMC
http://dx.doi.org/10.4088/pcc.v09n0611iDOI Listing

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Article Synopsis
  • Lamotrigine has been linked to serious blood-related side effects, especially with high starting doses or rapid dose increases.
  • A 29-year-old woman developed severe neutropenia after being on a high initial dose of lamotrigine for two weeks.
  • The timing of starting lamotrigine shortly after phenytoin, along with quick dose escalation, likely contributed to her blood disorder.
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