Neurotoxic metal-induced oxidative damage to nervous tissue has been implicated in several progressive neurodegenerative disorders including Alzheimer's disease. In this study, using human brain cells in primary culture, the quenching of metal sulfate-induced reactive oxygen species (ROS) and ROS-sensitive gene expression was studied using the antioxidants ascorbate, folic acid, phenyl butyl nitrone and the chelators desferrioxamine and Feralex-G. Antioxidants ascorbate, folic acid, phenyl butyl nitrone, desferrioxamine or Feralex-G were found to quench ROS and cPLA2 and COX-2 gene induction to various degrees, and a synergism was observed when certain combinations of them were used. These findings support the idea that specific antioxidants and metal ion chelators when used together can effectively and synergistically quench ROS-mediated induction of pathogenic gene expression.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/WNR.0b013e3282f4cb7e | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Monomeric tri-coordinated bis(ferrocenyl)haloalumanes.
Dalton Trans
January 2025
Graduate School of Science and Technology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8571, Japan.
The reactions of the sterically demanding ferrocenyl lithium dimer (Fc*Li) (Fc* = 2,5-bis(3,5-di--butyl-phenyl)-1-ferrocenyl) with aluminum trihalides (AlCl, AlBr, and AlI) to furnish the corresponding monomeric bis(ferrocenyl)haloalumanes are reported. In the case of the reaction with AlI, an unexpected intramolecular 1,1'-aluminum migration in the ferrocenyl moiety was found to occur. Their monomeric structures with a tri-coordinated aluminum atom show affinitive Al⋯Fe interactions.
View Article and Find Full Text PDFQuantitative Determination of a Series of Oxysterols by an Optimized LC-MS/MS Analysis in Different Tissue Types.
Int J Mol Sci
December 2024
School of Public Health, Capital Medical University, Beijing 100069, China.
Oxysterols, as metabolites of cholesterol, play a key role in cholesterol homeostasis, autophagosome formation, and regulation of immune responses. Disorders in oxysterol metabolism are closely related to the pathogenesis of neurodegenerative diseases. To systematically investigate the profound molecular regulatory mechanisms of neurodegenerative diseases, it is necessary to quantify oxysterols and their metabolites in central and peripheral biospecimens simultaneously and accurately.
View Article and Find Full Text PDFAnalysis of Pz-1, a promising therapeutic for organophosphorus poisoning from rodent plasma by liquid chromatography-tandem mass spectrometry.
J Pharm Biomed Anal
December 2024
Department of Chemistry, Biochemistry and Physics, South Dakota State University, Box 2202, Brookings, SD 57007, USA. Electronic address:
Organophosphorus (OP) pesticides (e.g., parathion) and nerve agents (e.
View Article and Find Full Text PDFDimethylacridine based emitters for non-doped organic light-emitting diodes with improved efficiency.
Chem Asian J
January 2025
Fujian Agriculture and Forestry University, College of Materials Engineering, No. 63, Xiyuangong Road, Minhou County, 350108, Fuzhou, CHINA.
Organic light-emitting diodes (OLEDs) has been attracting much extensive interest owing to their advantages of high-definition and flexible displays. Many advances have been focused on boosting the efficiency and stability. Two innovative dimethylacridine-based emitters,1,1,2,2-tetrakis(4- (2,7-di-tert-butyl-9,9-dimethylacridin-10(9H)-yl)phenyl ethene (AcTPE), and bis(4-(2,7-di-tert-butyl-9,9-dimethylacridin-10(9H)-yl)phenyl)methanone (Ac2BP) were designed and synthesized, in which TPE-baesed AcTPE presents AIE properties, and with the phenyl as spacer between the DMAC and carbony, aryl-ketone-based Ac2BP doesn't show AIE properties due to the absence of restriction of intramolecular rotations.
View Article and Find Full Text PDFMolecule self-assembly of hydrangea-shaped hollow O, Cl -codoped graphite-phase carbon nitride microspheres for efficient N-(1,3-dimethyl butyl)-N'-phenyl-p-phenylenediamine quinone photodegradation and bacteria disinfection.
J Colloid Interface Sci
January 2025
College of Materials and Chemistry, China Jiliang University, 258 Xueyuan Street, Xiasha Higher Education Zone, Hangzhou 310018, China. Electronic address:
6PPD-quinone (6PPD-Q) as a derivative of the rubber antioxidant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), is attracting intensive attention due to the significant hazard to ecosystems. However, the effective management of this type of contaminant has been scarcely reported. Hydrangea-like hollow O, Cl-codoped graphite-phase carbon nitride microspheres (HHCN), featuring open pores were readily prepared by molecular self-assembly and utilized to address 6PPD-Q in an aqueous system for the first time.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!