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A rare case of late developing anti-E antibody in a pregnant female leading to severe hemolytic disease of the newborn: A missed follow-up in COVID-19 epoch.
Asian J Transfus Sci
November 2023
Department of Transfusion Medicine, All India Institute of Medical Sciences, New Delhi, India.
With the use of Anti-D prophylaxis for rhesus D-negative pregnant women, other Rh and non-Rh allo-antibodies have become relatively more important. The index case reports severe hemolytic disease of the newborn due to anti-E antibody in a full-term baby boy born to a COVID-19-positive mother. The antibody screening of the mother performed during Booking of pregnancy at 9 week of gestation was negative.
View Article and Find Full Text PDFHemolytic disease of fetus and newborn due to maternal AlloAnti-S antibody.
Asian J Transfus Sci
May 2023
Department of Transfusion Medicine, Saveetha Medical College and Hospitals, Chennai, Tamil Nadu, India.
Hemolytic disease of foetus and newborn (HDFN) is a disease characterized by the destruction of fetal red cells by the maternal antibodies which occurs due to allo immunization in the mother by feto-maternal blood group incompatibility. The antibodies most frequently implicated in HDFN may vary depending on the demographic location under consideration. In areas where RhIg administration is available, ABO antibodies are more commonly implicated.
View Article and Find Full Text PDFBackground: Alloantibodies for the Rh blood group are the most immunogenic antibodies found in the Chinese population, typically causing acute or delayed hemolytic transfusion reactions and fetal and neonatal hemolytic diseases. Autoantibodies are generally considered nonspecific, and approximately 50% of warm antibodies are secondary to a variety of diseases, especially hematologic tumors. In this case report, a rare autoantibody that mimics anti-C and anti-e specificity was identified.
View Article and Find Full Text PDFAlloantibody Identification: The Importance of Temperature, Strength Reaction and Enzymes-A Practical Approach.
Hematol Rep
December 2024
Diagnostic Department, Immunohematology and Transfusion Medicine, Policlinico Riuniti, Via Pinto 1, 71122 Foggia, Italy.
Red blood cell (RBC) alloimmunization and antibodies formation against non-self antigens on red cells may occur after blood transfusion, pregnancies or other exposures. The RBC alloimmunization rate varies from 2% to 6% according to recent studies. The antibody screen is performed to identify or confirm the presence of antibodies in patient's serum or plasma, as a preoperative or pretransfusion test.
View Article and Find Full Text PDFPlanning antepartum directed donations in preparation for neonatal cardiac surgery in the absence of compatible donors.
Transfusion
December 2024
Transfusion Medicine, Héma-Québec, Montréal, Québec, Canada.
Background: Homozygous inheritance of the R haplotype, characterized by the absence of the high frequency antigen Sec, as well as partial C and e antigens, is rare and is associated with potential for alloimmunization. Anti-Sec has been reported to be associated with a risk of delayed hemolytic transfusion reaction and hemolytic disease of the fetus and newborn (HDFN).
Results: We report the case of a 36-year-old pregnant woman with known sickle cell trait (SCT) and homozygous for the R haplotype with anti-Sec, anti-c, and anti-e.
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