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http://dx.doi.org/10.1111/j.1540-8159.2007.00944.x | DOI Listing |
Thromb Haemost
January 2025
Yale University Center for Outcomes Research and Evaluation, Boston, United States.
No abstract for this Commentary/Viewpoint. Glad to add if the Editorial Office sees necessary.
View Article and Find Full Text PDFJ Med Chem
December 2024
Drug Discovery and Biomedical Sciences, College of Pharmacy, University of South Carolina, 715 Sumter Street, Columbia, South Carolina 29208, United States.
FLT3-ITD (internal tandem duplication) is a key driver of acute myeloid leukemia (AML), and several FDA-approved drugs target this mutant kinase. This Viewpoint describes the discovery of inhibitors targeting point mutants and the development of SILA123, a highly potent and selective type II FLT3 inhibitor. In studies, SILA-123 significantly suppressed tumor growth in allograft models, demonstrating its potential in treating resistant AML.
View Article and Find Full Text PDFJAMA
December 2024
Department of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
JAMA
December 2024
Rutgers Institute for Nicotine & Tobacco Studies, New Brunswick, New Jersey.
JAMA Ophthalmol
January 2025
Department of Medicine, Division of Pharmacoepidemiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
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