AI Article Synopsis
- The study focused on identifying proctolin antagonists from insect-derived peptides due to ongoing challenges with their effects.
- Researchers synthesized a native decapeptide from Manduca sexta and its 11 analogs, along with a growth suppressor pentapeptide from Antheraea yamamai and its 10 modified versions.
- Biological testing revealed that certain peptides stimulated heart rates in Tenebrio molitor, while others, particularly the modified ones, significantly inhibited heart rate.
Article Abstract
The subject of these studies was a search for proctolin antagonists among peptides originating from insect species because the proctolin antagonists constantly pose a problem. During these studies we performed the synthesis of the following peptides: a native decapeptide from Manduca sexta Mas-MT-I and its 11 analogs with shortened sequences at the N-end as well as a growth suppressor, a pentapeptide isolated from Antheraea yamamai, Any-GS and its 10 analogs, modified at position 1 and with a shortened peptide chain. Biological effects were evaluated by the cardiotropic test on the semi-isolated heart of the insect species Tenebrio molitor. Mas-MT-I and six analogs stimulate the heartbeat frequency, especially [6-10]-Mas-MT-I, whereas the [4-10]-Mas-MT-I analog shows a strong inhibition of the heartbeat frequency, if insect. The Any-GS and the analogs [Gln(1)]- and [Gly(1)]-Any-GS also show a strong cardioinhibitory effect.
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| http://dx.doi.org/10.1002/psc.977 | DOI Listing |
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