AI Article Synopsis
- - A new series of CRF-1 receptor antagonists, called 1-aryl-4-alkylaminoisoquinolines, has been designed and synthesized.
- - Researchers studied how different substitutes on the aromatic ring, amino group, and isoquinoline core affect the binding to the CRF-1 receptor.
- - The work focuses on understanding the structural relationships that enhance the binding effectiveness of these antagonists.
Article Abstract
The design, synthesis and structure-activity relationships of a novel series of CRF-1 receptor antagonist, the 1-aryl-4-alkylaminoisoquinolines, is described. The effects of substitution on the aromatic ring, the amino group and the isoquinoline core on CRF-1 receptor binding were investigated.
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| http://dx.doi.org/10.1016/j.bmcl.2007.12.050 | DOI Listing |
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