AI Article Synopsis

  • - The effectiveness of calcineurin inhibitors in kidney transplant patients is closely linked to how their drug levels are monitored, specifically looking at the area under the concentration-time curve (AUC).
  • - For cyclosporine (CYA), blood levels are typically checked 2 hours after taking the drug, while for tacrolimus (TAC), levels are measured just before the next dose (trough concentration).
  • - This study compared the blood concentration patterns of CYA and TAC in kidney transplant patients with similar backgrounds, revealing notable differences in their pharmacokinetics and how their levels relate to AUC.

Article Abstract

The clinical efficacy of calcineurin inhibitors administered to renal transplant patients is considered to be a strong function of the area under the concentration time curve (AUC). Interestingly, monitoring timings of blood concentrations for two similar calcineurin inhibitors, cyclosporine (CYA; Neoral) and tacrolimus (TAC; Prograf) are different. Namely, CYA blood concentration is usually monitored at 2 h after administration (C(2)) substituted for peak concentration (C(p)) and TAC at trough concentration (C(t)). In the literature, data describing such characteristics of CYA and TAC have been presented in the past. However, each of these patient groups had different backgrounds. We have attempted to examine the behavior of blood concentration curves simultaneously for both CYA and TAC by establishing controlled groups of renal transplant patients with similar clinical backgrounds. Furthermore, we have analyzed the correlation with C(p) and C(t) versus AUC implementing area under the trough level (AUTL), or area above the trough level (AATL) as new pharmacokinetic parameters, such that C(2) for CYA and C(t) for TAC have been verified using controlled clinical data. We have also found distinct differences in the pharmacokinetics between CYA and TAC with the relationships between AUC, C(p), and C(t).

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Source
http://dx.doi.org/10.1248/bpb.31.90DOI Listing

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