AI Article Synopsis
- BMPs are a group of proteins related to bone development, with BMP-2 being crucial for bone cell differentiation and developmental patterns.
- Researchers identified and analyzed the BMP-2 gene in the oyster species Pinctada fucata, revealing it has 447 amino acids and shares high sequence similarity with both oyster and human BMP-2.
- The expression of the BMP-2 gene was notably strong in the mantle tissue, indicating its significant role in the formation of the nacreous shell layer.
Article Abstract
The bone morphogenetic proteins (BMPs) constitute a subfamily of the transforming growth factor type beta (TGF-beta) supergene family. BMP-2 plays an important role not only in osteoblast differentiation but also in pattern formation during development. To determine the function of BMP-2 in Pinctada fucata development and hard tissue formation, we isolated a BMP-2 genomic DNA clone and the BMP-2 cDNA. The deduced BMP-2 sequence consisted of 447 amino acids. The BMP-2 gene was composed of three exons. The C-terminal portion (149 amino acids) had 86% and 66% identity to the Crassostrea gigas and the human BMP-2 sequence respectively. The 5' flanking promoter region contained putative glioma transcription factor (Gli) and retinoic acid receptor (RAR) responding elements. The BMP-2 gene was expressed strongly in the inner part of the mantle tissue, corresponding to the nacreous aragonite shell layer. This finding suggests that BMP-2 has a key role in nacreous layer formation.
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| http://dx.doi.org/10.1271/bbb.70302 | DOI Listing |
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