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An accessible workflow for high-sensitivity proteomics using parallel accumulation-serial fragmentation (PASEF).
Nat Protoc
January 2025
Department Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.
Deep and accurate proteome analysis is crucial for understanding cellular processes and disease mechanisms; however, it is challenging to implement in routine settings. In this protocol, we combine a robust chromatographic platform with a high-performance mass spectrometric setup to enable routine yet in-depth proteome coverage for a broad community. This entails tip-based sample preparation and pre-formed gradients (Evosep One) combined with a trapped ion mobility time-of-flight mass spectrometer (timsTOF, Bruker).
View Article and Find Full Text PDFIncorporating spatial and genetic competition into breeding pipelines with the R package gencomp.
Heredity (Edinb)
January 2025
Department of General Biology, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil.
Genetic competition can obscure the true merit of selection candidates, potentially leading to altered genotype rankings and a divergence between expected and actual genetic gains. Despite a wealth of literature on genetic competition in plant and animal breeding, the separation of genetic values into direct genetic effects (DGE, related to a genotype's merit) and indirect genetic effects (IGE, related to the effects of a genotype's alleles on its neighbor's phenotype) in linear mixed models is often overlooked, likely due to the complexity involved. To address this, we introduce gencomp, a new R package designed to simplify the use of (spatial-) genetic competition models in crop and tree breeding routines.
View Article and Find Full Text PDFSimplified segmental scleral buckling without localization and cryopexy: A retrospective comparison with conventional segmental scleral buckling.
Taiwan J Ophthalmol
January 2024
Department of Ophthalmology, National Taiwan University Hospital, Yunlin Branch, Yunlin, Taiwan.
Purpose: The aim of this study was to propose a simplified segmental scleral buckling (SSSB) technique that does not require break localization for less-experienced vitreoretinal surgeons.
Materials And Methods: This retrospective study compared the clinical results of 46 conventional and 23 SSSB (conventional segmental SB [CSSB] and SSSB, respectively) procedures in a tertiary referral retinal center in Taiwan between 2008 and 2019. In the CSSB group, breaks were localized during surgery.
Improving the performance of echo state networks through state feedback.
Neural Netw
December 2024
Wyant College of Optical Sciences, University of Arizona, Tuscon, AZ, USA. Electronic address:
Reservoir computing, using nonlinear dynamical systems, offers a cost-effective alternative to neural networks for complex tasks involving processing of sequential data, time series modeling, and system identification. Echo state networks (ESNs), a type of reservoir computer, mirror neural networks but simplify training. They apply fixed, random linear transformations to the internal state, followed by nonlinear changes.
View Article and Find Full Text PDFSimplified Medication Adherence Questionnaire (SMAQ) for People Living With HIV in a National Hospital in Mexico: Instrument Validation Study.
Interact J Med Res
January 2025
Research Institute, Facultad de Ciencias de la Comunicación, Turismo y Psicología, University of San Martín de Porres, Lima, Peru.
Background: Adherence to antiretroviral therapy is a critical component in achieving viral suppression in people living with HIV in addition to increasing overall quality of life. Several indirect methods have been used to measure adherence including the Simplified Medication Adherence Questionnaire (SMAQ).
Objective: The objective of this study is to evaluate the reliability and validity of the SMAQ in men living with HIV/AIDS attending a Mexican national hospital.
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