Medical treatments including intravenous vitamin D therapy often fail to control parathyroid hormone (PTH) level in advanced secondary hyperparathyroidism (SHPT) . High level of PTH in spite of hypercalcemia rssults from poor sensitivity for calcium (Ca) of parathyroid cell (PTC) , due to low content of Ca-sensing receptor (CaSR) . It has been reported that direct vitamin D injection into parathyroid gland (PTG) efficiently decreased PTH level without significant changes of Ca level in dialysis patients as well as in uremic animals, possibly through up-regulation of CaSR and vitamin D receptor and decrease of cell number in PTC. In addition, the increase of CaSR expression in PTC induced by gene therapy using the same technique of direct injection into PTG has been also confirmed in model animals. These new therapeutic strategies for increasing CaSR expression in PTC may be promising for the the control of Ca and PTH levels in patients with advanced SHPT.
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Neuropharmacology
January 2025
Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229, USA. Electronic address:
Kappa opioid receptors (KOR) expressed by peripheral pain-sensing neurons (nociceptors) are a promising target for development of effective and safer analgesics for inflammatory pain that are devoid of central nervous system adverse effects. Here we sought to delineate the signaling pathways that underlie peripheral KOR-mediated antinociception in adult male and female Sprague-Dawley rats. In an inflammatory model of pain, local intraplantar (i.
View Article and Find Full Text PDFJ Control Release
January 2025
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China. Electronic address:
Bone defects caused by osteoporosis, infection, diabetes, post-tumor resection, and nonunion often cause severe pain and markedly increase morbidity and mortality, which remains a significant challenge for orthopedic surgeons. The precise local treatments to these pathological complications is essential to avoid poor or failed bone repair. Hydrogel formulations serve as injectable innovative platforms that overcome microenvironmental obstacles and as delivery systems for controlled release of various bioactive substances to bone defects in a targeted manner.
View Article and Find Full Text PDFNeuro Oncol
January 2025
Department of Medicine, Division of Experimental Medicine, McGill University.
Background: Glioblastoma is an aggressive brain cancer with a 5-year survival rate of 5-10%. Current therapeutic options are limited, due in part to drug exclusion by the blood-brain barrier, restricting access of targeted drugs to the tumor. The receptor for the type 1 insulin-like growth factor (IGF-1R) was identified as a therapeutic target in glioblastoma.
View Article and Find Full Text PDFBroadband minimalist wireless base stations without energy-consuming electrical power amplifiers are the rosy scenario of the next-generation wireless communication systems. High-power radio-over-fiber (RoF) links, which are featured by large operation bandwidths, are regarded as the supporting technology for realizing such a vision. Nevertheless, the severe signal-to-noise ratio (SNR) deterioration induced by the second Brillouin scattering in high-power and long-distance RoF links must be first solved.
View Article and Find Full Text PDFBiofabrication
January 2025
Biomedical Engineering Department, Technion Israel Institute of Technology, Technion City, Haifa 32000, Haifa, Haifa, 3200003, ISRAEL.
Best cosmetic outcomes of breast reconstruction using tissue engineering techniques rely on the scaffold architecture and material, which are currently both to be determined. This study suggests an approach for a rational design of breast-shaped scaffold architecture, in which structural analysis is implemented to predict its stiffness and adjust it to that of the native tissue. This approach can help achieve the goal of optimal scaffold architecture for breast tissue engineering.
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