The aim of the article was the evaluation of the efficiency of decompression of biliary tracts and determination of optimal period of external draining. The biochemical rates of functional state of liver, dynamic of factors of humeral nonspecific defense in blood serum and bile, in 197 patients with obstructive jaundice were investigated. Concurrently, the dynamic of nonspecific defense reaction changes in infected hepatic bile, changes of amylase, pH, and bile hypertensia were studied. The obtained data are used to determine optimal period of external draining of biliary tracts. The investigation showed that early decompression of biliary tracts allows fast restore of the liver function. Restoration of natural resistance and their positive dynamic depends on the period of performance of external draining; to a lesser degree it depends on the method of performance.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Pharmacological and structural insights into nanvuranlat, a selective LAT1 (SLC7A5) inhibitor, and its N-acetyl metabolite with implications for cancer therapy.
Sci Rep
January 2025
Department of Bio-System Pharmacology, Graduate School of Medicine, Osaka University, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.
L-type amino acid transporter 1 (LAT1, SLC7A5), overexpressed in various cancers, mediates the uptake of essential amino acids crucial for tumor growth. It has emerged as a promising target for cancer therapy. Nanvuranlat (JPH203/KYT-0353), a LAT1 inhibitor, has shown antitumor activity in preclinical studies and efficacy in biliary tract cancer during clinical trials.
View Article and Find Full Text PDFGlobal, regional, and national burden of gallbladder and biliary tract cancer, 1990 to 2021 and predictions to 2045: An analysis of the global burden of disease study 2021.
J Gastrointest Surg
January 2025
Department of Hepatobiliary and Pancreatic Surgery, Fuyang People's Hospital, Fuyang 236000, China. Electronic address:
Background: Identifying past, present, and future temporal trends in gallbladder and biliary tract cancer (GBTC) can increase public awareness and promote changes in prevention and treatment strategies.
Methods: The incidence and death rates of GBTC between 1990 and 2021 were extracted from the Global Burden of Disease 2021 study and assessed according to country, region, year, age, and sex. Time trends were measured using the average annual percentage change (AAPC) and projections of the burden of disease for 2022-2045 were made using the Bayesian age-period-cohort model.
Metagenomic next-generation sequencing for the detection of bacterial translocation in the blood of patients following liver, biliary tract or pancreatic surgery.
Br J Surg
December 2024
Department of Hepato-biliary-pancreatic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Surgical approach to a biliary tract cyst in an elderly cat.
Vet Res Commun
January 2025
School of Agricultural Sciences, Innovation and Business, University of Passo Fundo, Passo Fundo, Brazil.
Choledochal cyst or biliary tract cyst is a pathological condition characterized by abnormal dilation of the hepatobiliary system. In veterinary medicine, case descriptions and histological characterizations of this biliary malformation are scarce, requiring reliance on data from human medicine. A presumptive diagnosis typically involves imaging studies, with histopathological examination required for confirmation.
View Article and Find Full Text PDFA review of F-18 fluorodeoxyglucose PET/CT in the evaluation and treatment of hepatobiliary tumors.
Q J Nucl Med Mol Imaging
December 2024
Nuclear Medicine, Radiology, University of Texas Southwestern, Dallas, TX, USA.
Hepatocellular carcinoma (HCC) and biliary tract cancers (BTC) pose significant diagnostic and therapeutic challenges. Magnetic resonance imaging (MRI) and multiphase computed tomography (CT) have been the preferred imaging modalities for diagnosis, staging, and surveillance of patients with these malignancies. The best clinical outcomes depend on the appropriate selection of treatment options from the tools available in neo-adjuvant therapy, surgical resection, locoregional therapy, liver transplantation, and adjuvant therapy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!