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[Synthesis and antiviral activity of lupane triterpenoids with modified cycle E]. | LitMetric

A reductive transformation of the peroxide products of ozonolysis of derivatives of 3beta-O-acetyl-22(17-->28)-abeo-lupa-17(28),20(29)-diene and the subsequent intramolecular ketalization led to a compound with a trioxane fragment. This is a new approach to a skeletal modification of triterpenoid cycle E. An activity of the synthesized compounds was found toward the viruses of type A influenza and herpes simplex.

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http://dx.doi.org/10.1134/s1068162007060088DOI Listing

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