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Estimation and Characterization of Dengue Serotypes in Patients Presenting with Dengue Fever at Makkah Hospitals.
Trop Med Infect Dis
January 2025
Department of Research, PMO, Ministry Branch in Makkah Region, Ministry of Health (MOH), Makkah 21955, Saudi Arabia.
Dengue fever is caused by four common serotypes of the dengue virus (DENV-1, DENV-2, DENV-3, and DENV-4). Patients infected with one serotype may develop lifelong serotype-specific protective immunity. However, they remain susceptible to reinfection with the other serotypes, often increasing the risk of severe forms of dengue.
View Article and Find Full Text PDFResults of 331 Two-Stage Exchanges for PJI Following THA: Low Reinfection and Mechanical Failure Rates at 10 Years.
J Bone Joint Surg Am
January 2025
Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.
Background: The relative advantages and disadvantages of 2-stage versus 1-stage management of infection following total hip arthroplasty (THA) are the current subject of intense debate. To understand the merits of each approach, detailed information on the short and, importantly, longer-term outcomes of each must be known. The purpose of the present study was to assess the long-term results of 2-stage exchange arthroplasty following THA in one of the largest series to date.
View Article and Find Full Text PDFHeterogeneity in Risk and Implications for Hepatitis C Reinfection in People Who Inject Drugs in England.
J Viral Hepat
February 2025
Statistics, Modelling and Economics Department, UK Health Security Agency, London, UK.
Chronic hepatitis C virus (HCV) infection is associated with significant morbidity, mortality and health economic burden. Over 90% of HCV cases in England occur in people who inject drugs (PWID). Current treatments for HCV are effective but do not protect against reinfection.
View Article and Find Full Text PDFNucleocapsid Antibodies as an Optimal Serological Marker of SARS-CoV-2 Infection: A Longitudinal Study at the Thomayer University Hospital.
J Clin Lab Anal
January 2025
Department of Clinical Biochemistry, Thomayer University Hospital, Prague, Czech Republic.
Background: The longitudinal study was conducted over the initial 2 years of the COVID-19 pandemic, spanning from June 2020 to December 2022, in healthcare workers (HCWs) of the Thomayer University Hospital. A total of 3892 blood samples were collected and analyzed for total nucleocapsid (N) antibodies. The aim of the study was to evaluate the dynamics of N antibodies, their relationship to the PCR test, spike (S) antibodies, interferon-gamma, and prediction of reinfection with SARS-CoV-2.
View Article and Find Full Text PDFPredicting higher risk factors for COVID-19 short-term reinfection in patients with rheumatic diseases: a modeling study based on XGBoost algorithm.
J Transl Med
December 2024
Department of Rheumatology and Immunology, Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Tianhe District, Guangzhou, China.
Background: Corona virus disease 2019 (COVID-19) reinfection, particularly short-term reinfection, poses challenges to the management of rheumatic diseases and may increase adverse clinical outcomes. This study aims to develop machine learning models to predict and identify the risk of short-term COVID-19 reinfection in patients with rheumatic diseases.
Methods: We developed four prediction models using explainable machine learning to assess the risk of short-term COVID-19 reinfection in 543 patients with rheumatic diseases.
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