AI Article Synopsis
- The study focuses on creating a water-soluble nanoemulsion of the lipid-soluble drug tamoxifen (TAM) to enhance its effectiveness.
- The nanoemulsion exhibited a higher zeta potential, which is linked to improved drug and membrane permeability compared to traditional TAM suspensions.
- In laboratory tests, the nanoemulsion showed significantly greater anti-cancer effects, reducing cell proliferation by 20 times and increasing cell death by 4 times in breast cancer cells compared to larger TAM particle suspensions.
Article Abstract
This paper reports on the preparation of a water-soluble nanoemulsion of the highly lipid-soluble drug tamoxifen (TAM). In addition, relative to a suspension of TAM, the nanoemulsion preparation demonstrated a greater zeta potential (increased negative charge) which has previously been associated with increasing drug/membrane permeability. This study also reports that relative to suspensions of TAM with particle sizes greater than 6000 nm, nanoemulsions of TAM, having mean particle sizes of 47 nm, inhibited cell proliferation 20-fold greater and increased cell apoptosis 4-fold greater in the HTB-20 breast cancer cell line. Thus, this work suggests that a nanoemulsion compared to a suspension preparation of TAM increases its anticancer properties relative to breast cancer.
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| http://dx.doi.org/10.1021/mp700091j | DOI Listing |
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