Hemophagocytosis is defined by a systemic macrophages activation, phagocyting the blood elements. This syndrome can be primary or secondary to multiple causes such as neoplasia or infections. We report here the first case of a hemophagocytosis caused by an Escherichia coli infection of ascitis fluid.
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Population pharmacokinetics and dosing simulations of temocillin in liver transplanted paediatric patients: a prospective, open-label, non-randomized study.
Clin Microbiol Infect
December 2024
Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium. Electronic address:
Objectives: Temocillin is a β-lactam antibiotic used for preventing or treating bacterial infections in liver-transplanted children. We characterized its pharmacokinetics in plasma and ascitic fluid and proposed dosing regimens that maximize achievement of effective drug exposures in this patient group.
Methods: Patients aged 6-36 months received 25 mg/kg/12h (n=14) or 25 mg/kg/8h (n=23).
Liver Cirrhosis: ancient disease, new challenge.
Med Clin (Barc)
December 2024
Servicio de Hepatología, Hospital Clínic de Barcelona, Barcelona, España; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalunya, España; Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, España; Facultad de Medicina y Ciencias de la Salud, Universidad de Barcelona, Barcelona,, España. Electronic address:
Liver cirrhosis is a common cause of morbidity and mortality worldwide. Excessive alcohol consumption and metabolic associated steatotic liver disease are the most common etiological factors of cirrhosis in our region. Cirrhosis occurs in two well-differentiated phases, compensated and decompensated, depending on the absence or presence of complications, respectively.
View Article and Find Full Text PDFSensitivity of diagnosis of spontaneous bacterial peritonitis is higher with the automated cell count method.
World J Hepatol
November 2024
Microbiology Service, University Hospitals Plymouth NHS Trust, Plymouth PL6 8DH, United Kingdom.
Background: Spontaneous bacterial peritonitis (SBP) is one of the most important complications of patients with liver cirrhosis entailing high morbidity and mortality. Making an accurate early diagnosis of this infection is key in the outcome of these patients. The current definition of SBP is based on studies performed more than 40 years ago using a manual technique to count the number of polymorphs in ascitic fluid (AF).
View Article and Find Full Text PDFEnhancing ascitic fungal infection diagnosis through next-generation sequencing: a pilot study in surgical ICU patients.
Front Cell Infect Microbiol
November 2024
Institute of Medical Microbiology and Hygiene, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Objectives: Ascites, often associated with critical pathologies such as liver cirrhosis or bowel perforation, can be complicated by fungal infection, increasing mortality especially in intensive care settings and demanding rapid diagnosis and adequate treatment. Traditional microbiological diagnostic methods have limited sensitivity in accurately identifying fungal pathogens in ascitic fluid. Alternative diagnostic methods may offer important insights to enable guiding of antifungal therapy and refining empirical treatment strategies.
View Article and Find Full Text PDFPeritoneal tuberculosis: the diagnostic challenge must not preclude treatment.
BMJ Case Rep
November 2024
Internal Medicine Department, Coimbra University Hospital Centre, Coimbra, Portugal.
Article Synopsis
- Peritoneal tuberculosis is a rare form of TB that occurs outside the lungs, primarily affecting individuals in countries with high TB prevalence, making travel from these areas a risk factor.
- Diagnosing this condition is challenging due to overlapping symptoms with other illnesses, which can delay treatment and worsen outcomes.
- A case study highlights a woman in her mid-50s who experienced severe symptoms, leading to various diagnostic procedures, with TB ultimately isolated from her fluid, allowing her to successfully complete a 6-month anti-TB treatment.
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