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Vaccines in a time of global boiling and megacities.
Trends Parasitol
January 2025
Texas Children's Hospital Center for Vaccine Development, Department of Pediatrics and Molecular Virology and Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Department of Biology, Baylor University, Waco, TX 76706, USA; James A. Baker III Institute of Public Policy, Rice University, Houston, TX 77005, USA; Hagler Institute for Advanced Study and Scowcroft Institute of International Affairs, The Bush School of Government & Public Service, Texas A&M University, College Station, TX 77843, USA. Electronic address:
Neglected tropical diseases are accelerating because of climate change and urbanization to create new clusters of vast urban areas beset by poverty and environmental degradation. These hot and contaminated megacities could enable the rise of parasitic and other tropical infections. A new generation of antiparasitic vaccines will be needed.
View Article and Find Full Text PDFHigh prevalence of soil-transmitted helminths among primary students in Ha Giang, Vietnam: A descriptive cross-sectional study.
Medicine (Baltimore)
January 2025
Thang Long Institute of Medical and Pharmaceutical Research, Hanoi, Vietnam.
Despite improvements in environmental sanitation and healthcare, the infection rate of soil-transmitted helminths (STHs) remains high in low socioeconomic regions of developing countries including Vietnam. This study aimed to determine the prevalence and intensity of STH infections among primary school children in Meo Vac, Ha Giang: a poor mountainous province in Vietnam. A descriptive cross-sectional study was conducted from October to November 2023, involving 400 participants.
View Article and Find Full Text PDFEfficacy and safety of ivermectin-albendazole combination versus ivermectin or albendazole monotherapy in soil-transmitted helminthiasis: A systematic review and meta-analysis.
Medicine (Baltimore)
January 2025
Department of Medicine, Manipal College of Medical Sciences, Pokhara, Nepal.
Background: Soil-transmitted helminthiasis remains a daunting challenge to global health, exerting its greatest toll on resource-limited regions of the world. A dual drug approach using the co-administration of ivermectin and albendazole has shown promising results in comparison to the traditional monotherapy strategy. In light of this, a systematic review and meta-analysis of randomized controlled trials was conducted.
View Article and Find Full Text PDFProteomic characterization and comparison of the infective and adult life stage secretomes from Necator americanus and Ancylostoma ceylanicum.
PLoS Negl Trop Dis
January 2025
Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia.
More than 470 million people globally are infected with the hookworms Ancylostoma ceylanicum and Necator americanus, resulting in an annual loss of 2.1 to 4 million disability-adjusted-life-years. Current infection management approaches are limited by modest drug efficacy, the costs associated with frequent mass drug administration campaigns, and the risk of reinfection and burgeoning drug resistance.
View Article and Find Full Text PDFLoeffler's Syndrome Induced by the Transmigration of Strongyloides stercoralis to the Lungs: A Case Report and Literature Review.
Cureus
December 2024
Neurosurgery, Penn State College of Medicine, Hershey, USA.
Loeffler's syndrome is a rare, benign respiratory disease usually associated with peripheral eosinophilia, first described by Wilhelm Loeffler in 1932. It is caused by the larvae of helminths such as hookworms, , and S that transmigrate through the lungs during the active phase of infection. We present a case of a 53-year-old man who complained of a productive cough with intermittent hemoptysis and left-sided posterior chest pain.
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