Background: A single dose of preemptive gabapentin reduces postoperative pain and postoperative analgesic consumption. However, the optimal dose of preemptive gabapentin remains to be evaluated.
Methods: In this prospective study, we defined the median effective analgesic dose using an up-and-down sequential allocation technique of preemptive gabapentin in 67 patients undergoing elective posterior lumbar spinal fusion. The efficacy of the study drug was assessed by morphine consumption during the first 24 h postoperatively.
Results: The median effective analgesic dose (median value and 95% confidence interval) of gabapentin was 21.7 mg/kg (19.9-23.5 mg/kg).
Conclusion: Given the large dose of gabapentin needed, further powered studies are warranted to assess side effects.
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Department of Pharmacy, Shaanxi Provincial People's Hospital, Youyixi Road, Beilin District, Xi'an, Shaanxi, China.
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Research Center for Trauma in Police Operations, Directorate of Health, Rescue & Treatment, Police Headquarter, Tehran, Iran.
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Department of Pediatric Surgery, All India Institute of Medical Sciences, Patna, Bihar, India.
Article Synopsis
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Comparison of the Efficacy of Pregabalin and Gabapentin for Preemptive Analgesia in Laparoscopic Cholecystectomy Patients: A Randomised Double-Blind Study.
Cureus
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Department of Medicine and Surgery, S. Nijalingappa Medical College and H.S.K. Hospital and Research Centre, Bagalkot, IND.
Introduction Preemptive analgesia is now an essential step of perioperative pain management. Pregabalin and gabapentin, which are drugs primarily used in the treatment of neuropathic pain, are now being contemplated for use as preemptive analgesics. This study aimed to assess the effectiveness of gabapentin and pregabalin as preemptive analgesics.
View Article and Find Full Text PDFPre-Emptive Opioid-Sparing Medication Protocol Decreases Pain and Length of Hospital Stay in Children Undergoing Posterior Spinal Instrumented Fusion for Scoliosis.
Iowa Orthop J
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Department of Orthopedics, Shriners Children's Southern California, Pasadena, California, USA.
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