During arm elevation, the trunk may have both a postural and synergic role, but few 3-D experimental studies exist of the phenomenon, and the contribution of trunk rotations to arm elevation has not been studied in patients with frozen shoulder. Thirty healthy volunteers performed maximal dominant arm elevation in 2 planes, sagittal (anteflexion) and frontal (abduction), and 13 patients with unilateral frozen shoulder performed arm elevation on the unaffected then affected side. Trunk rotations and humeral elevation were measured with use of an electromagnetic system (Polhemus Fastrak). Flexion/extension, inclination (lateral bending) and torsion (rotation around the main axis) of the trunk were measured at intermediate (45 degrees and 60 degrees ) and maximal levels of arm elevation. For patients, trunk rotations were also measured during elevation on the unaffected side at a level corresponding to maximal arm elevation of the contralateral affected side. Healthy volunteers made a small (4 degrees -9 degrees ) but consistent pattern of trunk rotations characterized mainly by extension during anteflexion and torsion during abduction associated with biphasic inclination (ipsilateral then contralateral). As expected, patients showed restricted arm elevation of the affected shoulder but performed larger trunk extension and torsion at intermediate levels of elevation with a similar pattern as above. Inclination range was limited during elevation of the affected shoulder, with no initial ipsilateral inclination on any side. Our results suggest that the trunk contributes to the kinematic chain for arm elevation in both groups. Trunk extension and torsion may compensate for impaired arm elevation. Conversely, the irregularities in trunk inclination may contribute to the impairment and be a target for rehabilitative management.
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http://dx.doi.org/10.1016/j.brainres.2007.11.046 | DOI Listing |
World J Urol
January 2025
Department of Urology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Propose: This study aimed to evaluate the efficacy and safety of neoadjuvant treatment of darolutamide, a next-generation androgen receptor inhibitor, plus androgen deprivation therapy (ADT) for patients with locally advanced prostate cancer (LAPC).
Methods: This single-arm, multicenter, open-label phase II trial (ClinicalTrials.gov: NCT05249712, 2022-01-01), recruited 30 localized high-risk/very high-risk prostate cancer (HRPCa/VHRPCa) patients from three centers in China between 2021 and 2023.
Alzheimers Dement
December 2024
Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Background: Aging is a time-dependent deterioration of physiological functions that occurs in both humans and animals. Within the brain, aging cells gradually become dysfunctional through a complex interplay of intrinsic and extrinsic factors, ultimately leading to behavioral deficits and enhanced risk of neurodegenerative diseases such as Alzheimer's disease (AD). The characteristics of normal aging are distinct from those associated with age-related diseases and it is important to understand the processes that contribute to this pathological divergence.
View Article and Find Full Text PDFObstet Gynecol
January 2025
South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit and the Wits Infectious Diseases and Oncology Research Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, and the Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, SA-MRC Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa; the Vaccines and Immunity Team, Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, the Gambia; the Institute for International Health Charité, Universitätsmedizin, Berlin, Germany; Children's Hospital Colorado, Aurora, Colorado; Vaccine Research and Development, Pfizer Inc, Pearl River, New York; Vaccine Research and Development, Pfizer Inc, Hurley, United Kingdom; Instituto de Maternidad y Ginecología Nuestra Señora de Las Mercedes, San Miguel de Tucumán, Argentina; iTrials-Hospital Militar Central, Buenos Aires, Argentina; the Stanford University School of Medicine, Palo Alto, California; the Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington; and Worldwide Safety, Pfizer Srl, Milan, Italy.
Objective: To describe preterm birth frequency and newborn and infant outcomes overall and among preterm children in the MATISSE (Maternal Immunization Study for Safety and Efficacy) trial of maternal vaccination with bivalent respiratory syncytial virus (RSV) prefusion F protein-based vaccine (RSVpreF) to protect infants against severe RSV-associated illness.
Methods: MATISSE was a global, phase 3, randomized, double-blind trial. Pregnant individuals received single injections of RSVpreF or placebo.
Clin Orthop Relat Res
January 2025
Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Background: Deficient internal rotation after shoulder arthroplasty can inhibit specific essential activities of daily living that require behind-the-back arm positioning. Although postoperative internal rotation deficits occur, their impact on outcomes of total shoulder arthroplasty (TSA) is not well established. Previous authors have validated the Single Assessment Numeric Evaluation (SANE) as a patient-reported assessment of acceptable outcomes of TSA.
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