Bioassay-guided fractionation of an ethanol extract of a Madagascar collection of the fruits of Cordyla madagascariensis ssp. madagascariensis led to the isolation of the four new cassane diterpenoids 1-4. The 1H and 13C NMR spectra of all compounds were fully assigned using a combination of 2D NMR experiments, including COSY, HSQC, HMBC, and ROESY sequences. All of the isolates were tested against the A2780 human ovarian cancer cell line, and compounds 1 and 2 showed mild antiproliferative activity with IC50 values of 10 and 36 microM, respectively.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533136 | PMC |
| http://dx.doi.org/10.1021/np070437l | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pro-apoptotic and anti-proliferative activities of cassane diterpenoids on squamous carcinoma cells: An in vitro and in silico study.
Toxicol Rep
December 2024
Department of Oral and Maxillofacial Surgery, Facial Plastic Surgery, Rostock University, Medical Center, Schillingallee 35, Rostock 18057, Germany.
Squamous carcinoma of the head and neck is characterized by aberrant apoptosis that prolongs the proliferative capacity of the cells and by uncontrolled cell growth. This study aimed to examine the pro-apoptotic and antiproliferative effects of cassane diterpenoids on squamous carcinoma cells . The cytotoxicity of four (4) cassane diterpenoids {Six-cinnamoyl- 7-hydroxyvouacapen-5-ol(1), pulcherrimin A(2), C(3), and E(4)} isolated from C.
View Article and Find Full Text PDFA new cassane diterpenoid from the seed of .
J Asian Nat Prod Res
June 2024
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
In this study, a previously undescribed cassane diterpenoid, named caesalpinin JF (), along with two known cassane diterpenoids caesanine C () and tomocinol B (), was isolated from 95% EtOH extract of the seeds of Linn. Additionally, three known compounds including pulcherrin R (), syringaresinol-4'---D-glucopyranoside () and kaempferol () were also identified. The structures of the isolated compounds were elucidated by comprehensive 1D and 2D NMR spectroscopic analyses.
View Article and Find Full Text PDFStructurally diverse diterpenoids from the seeds of Caesalpinia minax Hance and their bioactivities.
Phytochemistry
September 2024
Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, 650504, China. Electronic address:
Eight previously undescribed diterpenoids, caesamins A-H (1-8), were separated and identified from the seeds of Caesalpinia minax Hance. Their structures were characterized by extensive spectroscopic data and X-ray crystallographic analysis. Structurally, caesamin A (1) is the first cassane-type diterpenoid with a C23 carbon skeleton containing an unusual isopropyl.
View Article and Find Full Text PDFAnti-pancreatic cancer activity of cassane diterpenoids isolated from the seeds of Caesalpinia sappan mediated by autophagy activation via ROS/AMPK/mTORC1 pathway.
Phytochemistry
June 2024
Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, 650504, PR China. Electronic address:
Three undescribed cassane diterpenoids, caesalpanins D-F (1-3), and seven known ones were isolated from the seeds of Caesalpinia sappan. Structures and absolute configurations of 1-3 were elucidated based on the extensive spectroscopic analysis, single-crystal X-ray diffraction analysis, and ECD calculations. Structurally, compound 1 was the first example of 18-norcassane diterpenoid and 2 was a rare 20-norcassane diterpenoid having an unusual five-membered oxygen bridge between C-10/C-18.
View Article and Find Full Text PDFTwo new cassane diterpenoids from the seed kernels of .
J Asian Nat Prod Res
March 2024
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
Two new cassane diterpenoids, sucupiranin MN () and sucupiranin ML (), together with two known compounds sucutinirane C () and deacetylsucutinirane C () were isolated from the seed kernels of . Their structures were elucidated by means of analysis of comprehensive spectroscopic data, especially HRESIMS and 1D/2D NMR spectroscopy. Compounds are typical furan-type cassane derivatives with an aromatized C ring.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!