Investigation of serrated roll surface differences on ribbon thickness during roller compaction.

Pharm Dev Technol

Pfizer Global Research and Development, Pfizer Inc., Groton, CT 06340, USA.

Published: February 2008

Many parameters are considered when developing a roller compaction process. However, roll serration volume is generally not considered when using serrated rolls. It was hypothesized that serration volume of concavo-convex rolls can have a significant effect on ribbon thickness due to differences in nip angle. Experiments were conducted to investigate ribbon thickness using different roll sets having a range of serration volumes. Roll sets with approximately twice the serration volume produce ribbons 20-25% greater in thickness. These results correlated with physical measurements taken of the serrations from each set. Thus, differences in roll serration volume can significantly affect ribbon thickness.

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http://dx.doi.org/10.1080/10837450701563012DOI Listing

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