A patient with acute myelomonocytic leukemia (M4), dysmegakaryocytopoiesis and thrombocytosis is presented. Immunophenotyping and blast colony assay showed the presence of blasts with IaDr, CD 33 and CD 14 antigens. Cytogenetic analysis and level of thrombopoietin were normal. This atypical case represents yet another example of the transitional zone between atypical myeloproliferative disease and acute leukemia, and the apparent absence of any cytogenetic abnormality is noteworthy.
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