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Background: Laparoscopic radical gastrectomy has been reported to be associated with substantial trauma and pain. This study compared the impact of ultrasound-(US)-guided, bilateral, double-injection intertransverse process block (ITPB) on postoperative analgesia with subcostal transversus abdominis plane block (TAPB) in patients who were undergoing laparoscopic radical gastrectomy.

Methods: Sixty-two patients who were undergoing laparoscopic radical gastrectomy surgery under general anesthesia were included.

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  • The study investigates the relationship between Bispectral Index (BIS) and age-adjusted Minimum Alveolar Concentration (aaMAC) during anesthesia maintenance in adults.
  • Factors such as age, ASA status, and specific anesthetic agents were found to influence BIS readings, indicating that older patients and those given certain drugs showed higher BIS at the same aaMAC.
  • A generalized estimation equation was developed to predict either BIS or aaMAC based on known values, despite significant variances in their relationship.
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Opioid-induced respiratory depression: clinical aspects and pathophysiology of the respiratory network effects.

Am J Physiol Lung Cell Mol Physiol

December 2024

The author is retired. The positions and affiliations are those prior to his retirement.

Important insights and consensus remain lacking for risk prediction of opioid-induced respiratory depression (OIRD), reversal of respiratory depression (RD), the pathophysiology of OIRD, and which sites make the most significant contribution to its induction. The ventilatory response to inhaled carbon dioxide is the most sensitive biomarker of OIRD. To accurately predict respiratory depression (RD), a multivariant RD prospective trial using continuous capnograph and oximetry examining 5 independent variables: age ≥60, sex, opioid naivety, sleep disorders, and chronic heart failure (PRODIGY trial), was undertaken.

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Introduction: The neuraxial morphine has been regarded as the gold standard for postpartum analgesia. However, the recent advancements in patient-controlled analgesia and various regional nerve blocks have led to the implementation of multimodal analgesia strategies, which aim to reduce opioid usage and associated complications while ensuring satisfactory pain relief. The objective of this research is to investigate the optimal dosage of epidural morphine for alleviating moderate and severe pain after caesarean sections in healthy parturients, as well as reducing unnecessary burden of respiratory monitoring resources.

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Article Synopsis
  • - The study aimed to determine how different sedation protocols (MVH, DH, H) affected the amount of alfaxalone needed for anesthesia in healthy Beagle dogs and to assess various cardiopulmonary metrics.
  • - In this experiment, dogs premedicated with MVH required less alfaxalone for induction compared to those given DH or H and experienced a higher incidence and duration of hypotension during anesthesia.
  • - The findings suggest that while MVH is effective for reducing alfaxalone dosage, it may lead to significant drops in arterial pressure, indicating a trade-off in its clinical use.
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