Objectives: Subjective sleep complaints have been reported in up to 80% of patients with end stage renal disease (ESRD). In these patients, sleep disturbances manifesting as insomnia, sleep apnea syndrome, restless leg syndrome (RLS), periodic limb movement disorder and excessive daytime sleepiness (EDS) have been frequently reported. Moreover, studies about the role of dialysis shift on sleep abnormalities, morbidity and mortality are still scarce. The aim of this study was to investigate the influence of dialysis shift on the quality of sleep and sleep abnormalities in patients with ESRD.
Methods: We studied one hundred consecutive patients from a dialysis center. Quality of sleep was assessed by the Pittsburgh Sleep Quality Index and subjective EDS by the Epworth Sleepiness Scale. Restless leg syndrome was diagnosed using the four minimum criteria defined by the International Restless Legs Syndrome Study Group. Clinical and laboratory parameters were obtained by interview and chart review. Adequacy of dialysis was evaluated by the Kt/V index.
Results: Poor quality sleep (PSQI>6) was found in 75% of cases and was associated with RLS (p=0.004) and with snoring (p=0.016). EDS (ESS>10) was present in 28% of cases. Patients with EDS (1.33+/-0.29) had lower values of the Kt/v index (P=0.01) than those without EDS (1.52+/-0.32). RLS was present in 48% of cases. Irrespective of dialysis shift, poor quality sleep, EDS and RLS were not different among patients.
Conclusion: Poor quality sleep, EDS and RLS were common and not related to dialysis shift.
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http://dx.doi.org/10.1590/s0104-42302007000600014 | DOI Listing |
Curr Pain Headache Rep
January 2025
The David S. and Ruth L. Gottesman Center for Headache Treatment and Translational Research at the Icahn School of Medicine at Mount Sinai, 5 East 98th Street, 7th Floor, New York, NY, 10029, USA.
Purpose Of Review: The objective of this review is to describe recent updates in the understanding of dialysis headache. These recent findings will be placed in a historical context that reviews the clinical features, classification, epidemiology, pathophysiology, and treatment of dialysis headache.
Recent Findings: There is something intrinsic to the dialysis procedure itself that leads to headaches in susceptible individuals.
Int J Biol Macromol
December 2024
Composites and Nanocomposites Center, Moroccan Foundation for Advanced Science, Innovation and Research, Rabat Design Center, Rue Mohamed El Jazouli, Madinat El Irfane, Rabat 10100, Morocco; Mohammed VI Polytechnic University, Lot 660 Hay Moulay Rachid, 43150 Ben Guerir, Morocco. Electronic address:
Int J Biol Macromol
December 2024
School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China; Shenyang Key Laboratory of Chinese Medicine targeted Delivery Key laboratory, China. Electronic address:
Ovarian cancer, a highly lethal form of gynecological cancer globally, has witnessed notable advancements in its treatment through the integration of nanotechnology and immunotherapy. Here, we designed a novel astragalus polysaccharide vector (PDA), encapsulating podophyllotoxin (PPT), and modifying methotrexate (DSPE-PEG-MTX) on its surface for targeting ovarian cancer cells with high folate receptor expression. We prepared novel MTX-modified PPT-loaded astragalus polysaccharide micelles (MTX-PPT-micelles) by dialysis method and evaluated their characterization, stability, safety and targeting ability.
View Article and Find Full Text PDFAm J Physiol Renal Physiol
December 2024
Division of Nephrology, Department of Medicine, Stony Brook University, , Stony Brook, NY.
Glomerular endothelial cell (GEnC) injury is a common feature across the wide spectrum of glomerular diseases. We recently reported that the endothelial-specific knockout of increases the susceptibility to GEnC injury and subsequent development of subacute thrombotic microangiopathy (TMA). However, the mechanism(s) mediating GEnCs response to injury in TMA are poorly understood.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
Polymer Reaction Design Group, School of Chemistry, Monash University, 19 Rainforest Walk, Building 23, Clayton, VIC 3800, Australia.
A continuous flow setup comprising an inline dialysis unit for immediate monomer removal is used for the depolymerization of poly(methyl methacrylate) (pMMA), synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. The approach used allows one to carry out solution depolymerizations at much higher polymer content compared to batch processes while maintaining high depolymerization conversions. pMMA is efficiently depolymerized in the flow reactor, yielding up to 68% monomer recovery under catalyst-free reaction conditions at 160 °C, starting from a 1 molar repeat unit concentration, which is a 20-fold improvement compared to previous batch studies.
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