Purpose: To evaluate findings of ophthalmologic examinations in cardiac transplant recipients, searching especially for changes in the retinal nerve fiber layer by means of Scanning Laser Polarimetry.
Methods: Fifteen cardiac transplant recipients were examined from September 2003 to July 2004. All of them underwent ophthalmologic examination, which consisted of visual acuity (VA), biomicroscopy, tonometry and fundoscopy. Fiber layer analyzer-GDx-examination was performed in eleven patients. Twelve patients were men. The mean age was 55.0+/-13.5 years. The follow-up since transplantation lasted from 3 to 74 months; mean value 29.7+/-20.8 months.
Results: VA with best correction in all patients attained at least 20/40. Subcapsular posterior cataract was seen in one patient; another presented corneal nubeculae secondary to herpes zoster. In one case a scar suggesting retinocoroiditis was seen at fundoscopy. Biomicroscopic and the fundoscopic findings were expected because of immunosuppressive treatment, following transplantation. GDx examination disclosed loss of fibers in the superior retinal fiber layer in 12 of the 22 examined eyes.
Conclusion: These results support the hypothesis that reduction of oxygen inflow in retinal circulation before or during heart transplantation could lead to loss of fibers in the retinal nerve fiber layer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1590/s0004-27492007000500008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: The early detection of neurologic damage at the microscopic level when the disease is subclinical would facilitate intervention preventing progression or potentially reversing the condition. The early determination of drug efficacy could shorten the length of drug studies, thereby reducing research costs. The eye is the only place in the body where an artery, vein, and nerve can be directly visualized The nerve fiber layer of the retina is an outgrowth of the brain.
View Article and Find Full Text PDFSecond harmonic generation imaging reveals entanglement of collagen fibers in the elephant trunk skin dermis.
Commun Biol
January 2025
Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK.
Form-function relationships often have tradeoffs: if a material is tough, it is often inflexible, and vice versa. This is particularly relevant for the elephant trunk, where the skin should be protective yet elastic. To investigate how this is achieved, we used classical histochemical staining and second harmonic generation microscopy to describe the morphology and composition of elephant trunk skin.
View Article and Find Full Text PDFDry eye disease and morphological changes in the anterior chamber in people with cystic fibrosis.
J Cyst Fibros
January 2025
Pulmonology Department, Regional University Hospital of Malaga, Department of Medicine and Dermatology, University of Malaga, Biomedical Research Institute of Malaga (IBIMA) - Bionand Platform, Malaga, Spain. Electronic address:
Background: Cystic fibrosis (CF) is caused by variants in a gene that encodes a protein essential for water and ion transport in the epithelial cells of exocrine organs. Given the possible relationship of this protein and conjunctival and corneal epithelium, the aim of this study was to evaluate ophthalmologic alterations in people with CF.
Methods: Forty-five people with CF underwent pulmonary evaluation including inflammatory score (IS).
Superelastic bamboo cellulose nanofiber based carbon aerogel with layered network microstructure for high sensitivity piezoresistive sensor.
Int J Biol Macromol
January 2025
School of Materials & Chemistry Architecture, Anhui Agricultural University, Anhui Healthy Sleep Home Furnishings Engineering Research Center, Hefei 230036, China. Electronic address:
Carbon aerogels, characterized by their high porosity and superior electrical performance, present significant potential for the development of highly sensitive pressure sensors. However, facile and cost-effective fabrication of biomass-based carbon aerogels that concurrently possess high sensitivity, high elasticity, and excellent fatigue resistance remains a formidable challenge. Herein, a piezoresistive sensor with a layered network microstructure (BCNF-rGO-CS) was successfully fabricated using bamboo nanocellulose fiber (BCNF), chitosan (CS), and graphene oxide (GO) as raw materials.
View Article and Find Full Text PDFTopographic Anatomy and Step-Wised Harvest of Intermuscular Occipital Artery in Far Lateral Approach.
World Neurosurg
January 2025
Xuanwu Hospital, Capital Medical University, Beijing, China; Samii Clinial Neuroanatomy Research and Education Center of Xuanwu Hospital, Beijing, China. Electronic address:
Background: The occipital artery (OA) is an important donor artery for intracranial and extracranial bypass surgery, but its path is tortuous, making it difficult to harvest. Part of the traditional intermuscular OA is not covered by muscle and is easily damaged during surgery. Currently, there are few reports on how to protect this segment of the OA.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!