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Malignant hypertension induces thrombotic microangiopathy and renal failure: A case report.
Medicine (Baltimore)
January 2025
Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China.
Rationale: Thrombotic microangiopathies (TMA) caused by malignant hypertension is an acute and critical disease among rare diseases. Although renal biopsy pathology is a golden indicator for diagnosing kidney disease, it cannot distinguish between primary and secondary TMA and requires a comprehensive diagnosis in conjunction with other laboratory tests and medical history.
Patient Concerns: A 33-year-old young man was hospitalized due to unexplained kidney failure.
Efficacy of Olmesartan/Amlodipine Single-Pill Combination on 24-h Mean Systolic Blood Pressure Measured by Ambulatory Monitoring in Non-Responders to Valsartan or Candesartan Monotherapy.
J Clin Hypertens (Greenwich)
January 2025
Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.
The aim of this study was to evaluate the efficacy of olmesartan/amlodipine (OLM/AML) single-pill combination (SPC) therapy using ambulatory blood pressure monitoring (ABPM) in non-responders to valsartan or candesartan monotherapy. Isolated systolic hypertension (ISH) is the most prevalent form of hypertension in middle-aged and elderly individuals. Patients aged over 55 years who did not achieve the target systolic blood pressure (SBP < 140 mmHg) with valsartan 80 mg or candesartan 8 mg for at least 4 weeks were included.
View Article and Find Full Text PDFChronic lymphoproliferative disorder of natural killer cells-related neurolymphomatosis with severe autonomic dysfunction: a case report.
BMC Neurol
September 2024
Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Article Synopsis
- Chronic lymphoproliferative disorder of natural killer cells (CLPD-NK) is a rare disease with high NK cell counts that is often asymptomatic, but can lead to symptoms like fatigue, fever, and autoimmune diseases.
- A 61-year-old male patient diagnosed with CLPD-NK experienced numbness and elevated protein levels in cerebrospinal fluid, indicating potential immunological issues, which were treated with steroids and immunoglobulin therapy.
- Despite treatment alleviating some symptoms, the patient developed significant autonomic dysfunction, leading to issues like diarrhea and orthostatic hypotension, while tests for specific antibodies were negative, and a nerve biopsy suggested lymphocytic infiltration.
Amitriptyline and duloxetine attenuate activities of superficial dorsal horn neurons in a rat reserpine-induced fibromyalgia model.
J Pharmacol Sci
November 2024
Department of Physical Therapy, Faculty of Rehabilitation, Niigata University of Health and Welfare, Niigata, 950-3198, Japan; Institute for Human Movement and Medical Sciences (IHMMS), Niigata University of Health and Welfare, Niigata, 950-3198, Japan. Electronic address:
Fibromyalgia (FM) is an intractable disease with a chief complaint of chronic widespread pain. Amitriptyline (AMI) and duloxetine (DLX), which are antidepressant drugs, have been reported to ameliorate pain in patients with FM and pain-related behaviors in several rodent models of FM. However, the mechanisms of action of AMI and DLX are not yet fully understood.
View Article and Find Full Text PDFCervical epidural blood patch treatment is a choice for spontaneous intracranial hypotension.
Technol Health Care
January 2025
Department of Anesthesiology, Chinese PLA General Hospital First Medical Center, Beijing, China.
Article Synopsis
- Epidural blood patch (EBP) is a simple and helpful treatment for a condition called spontaneous intracranial hypotension (SIH), but there hasn't been much focus on using it in the neck area.
- In a study with 59 patients, most of whom had bad headaches, the researchers checked how well cervical EBP worked and if it was safe.
- The results showed that many patients felt better after the treatment, with few side effects, and all patients were doing well at their follow-up visits.
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