Genital herpes is the main cause of genital ulcers worldwide; the prevalence of herpes simplex virus (HSV) type 2 infections in the general population ranges from 10% to 60%. Most genital herpes is caused by HSV-2, although HSV-1 accounts for about half of new cases in developed countries. The risk of HIV acquisition is three times higher in people with HSV-2. Neonatal herpes is an uncommon but serious complication of genital herpes. Most genital HSV-2 infections are unrecognised and undiagnosed; infected individuals, even with mild symptoms, shed HSV, and can infect sexual partners. Since clinical diagnosis is neither sensitive nor specific, virological and type-specific serological tests should be used routinely. Oral antiviral drugs for HSV infections are safe and effective and can be used both to treat episodes and to prevent recurrences. Antiviral treatment of the infected partners and condom use reduce the risk of sexual transmission of HSV-2.
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http://dx.doi.org/10.1016/S0140-6736(07)61908-4 | DOI Listing |
Kidney Med
April 2025
Division of Nephrology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Viral etiologies, such as herpes simplex virus (HSV), for peritonitis can be misclassified as culture negative peritonitis because of poor accessibility of viral testing in the effluent fluid. Inaccurate diagnosis and subsequent ineffective treatment can lead to unnecessary catheter removal for presumed refractory peritonitis. Here, we report a 73-year-old woman with a history of genital HSV-2 on continuous cyclic peritoneal dialysis who presented with HSV-2 related peritonitis.
View Article and Find Full Text PDFDermatologie (Heidelb)
March 2025
Universitätsklinik für Dermatologie und Allergologie, Klinikum Oldenburg, Rahel-Straus-Str. 10, 26133, Oldenburg, Deutschland.
Int J Nanomedicine
March 2025
University of Lodz, Faculty of Chemistry, Department of Materials Technology and Chemistry, Lodz, 90-236, Poland.
Introduction: In this paper, we discuss the influence of the ligand type present on the surface of silver nanoparticles (AgNPs) on its affinity to the virus surface and its virucidal activity against herpes simplex virus type 2 (HSV-2). We selected four different ligands, which potentially exhibit different affinity to the HSV-2 virus surface and used them for functionalization of AgNPs: i) sodium citrate: ii) tannic acid; iii) 1-mercaptoundecane-1-sulfonate (MUS); iv) and poly(ethylene glycol) (PEG).
Methods: The antiviral activity was performed by in vitro Vero cell culture.
Mol Divers
March 2025
Department of Mathematics, Bioinformatics and Computer Applications, Maulana Azad National Institute of Technology, Bhopal, Madhya Pradesh, 462003, India.
Herpes Simplex Virus 2 (HSV-2) infection is a global concern, affecting around 500 million individuals worldwide and being the leading cause of genital ulcers. Although several HSV vaccine candidates have been tested in humans, as of right now, neither HSV type has a licenced vaccination available. This study utilized reverse vaccinology to conduct an extensive analysis of the entire genome of HSV-2 where glycoprotein-D was chosen for T-cell epitope predictions.
View Article and Find Full Text PDFJ Clin Virol
March 2025
Virology Department, AP-HP, Saint-Louis Hospital, 75010 Paris, France. Electronic address:
Background: The landscape of diagnostic assays for detecting herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) antibodies (IgG) has evolved over time. This study aims to evaluate the analytical performance of Alinity-i chemiluminescence immunoassays in detecting specific anti-HSV-1 and HSV-2 IgG.
Methods: A retrospective analysis was conducted on 157 serum samples collected from 155 patients between June 2023 and July 2024.
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