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No longer to be ignored: Hypophosphatemia following intravenous iron administration.
Rev Endocr Metab Disord
December 2024
Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium.
Intravenous iron supplementation is increasingly used to safely and effectively correct iron deficiency anemia, but some formulations are linked to a renal phosphate wasting syndrome which is mediated by fibroblast growth factor 23. Unawareness among prescribers and the nonspecific clinical symptoms of hypophosphatemia result in underreporting of this complication. Even though it is often an asymptomatic and self-limiting condition, accumulating evidence from case reports and dedicated randomized controlled trials show that IV iron induced hypophosphatemia may be associated with clinical symptoms.
View Article and Find Full Text PDFVitamin D concentration in maternal serum during pregnancy: Assessment in Hokkaido in adjunct study of the Japan Environment and Children's Study (JECS).
PLoS One
November 2024
Faculty of Dental Medicine, Department of Orthodontics, Hokkaido University, Sapporo, Hokkaido, Japan.
Article Synopsis
- Vitamin D is crucial for bone health and has been linked to COVID-19 severity, but little is known about its levels in pregnant women in Hokkaido, Japan.
- The study measured vitamin D2 and D3 levels in 206 pregnant women and analyzed their relationship with seasonal changes and sunshine exposure.
- Results showed that nearly all participants were vitamin D deficient, highlighting the need for interventions to improve vitamin D levels for the health of pregnant women and their babies.
Presentation and outcome in carriers of pathogenic variants in SLC34A1 and SLC34A3 encoding sodium-phosphate transporter NPT 2a and 2c.
Kidney Int
January 2025
Department of Pediatric Kidney, Liver, Metabolic and Neurological Diseases, Hannover Medical School, Hannover, Germany. Electronic address:
Article Synopsis
- Pathogenic variants in the SLC34A1 and SLC34A3 genes, responsible for sodium-phosphate transport, lead to rare phosphate wasting conditions, primarily in children, with various clinical presentations and outcomes.
- A study analyzed data from 113 patients across 90 families, revealing distinct symptoms: SLC34A1 carriers mostly show issues in infancy, while SLC34A3 carriers experience symptoms into childhood and adulthood, including a significantly higher prevalence of chronic kidney disease in adulthood.
- Biochemical markers were similar for both groups, indicating some common underlying mechanisms, and phosphate treatment yielded partial improvements in certain enzyme levels but raised parathyroid hormone levels, suggesting a complex interaction between treatments and kidney function.
Prevalence of chondrocalcinosis and calcium pyrophosphate deposition disease in a cohort of adult patients with low alkaline phosphatase levels and a positive versus negative genetic study.
JBMR Plus
November 2024
Rheumatology Unit, La Paz University Hospital, Paseo de la Castellana, 261, 28046 Madrid, Spain.
Article Synopsis
- A study estimated how common chondrocalcinosis and CPPD are in patients with low alkaline phosphatase (ALP) levels and a genetic marker for hypophosphatasia (HPP), compared to those without the genetic marker.
- Results showed that chondrocalcinosis was significantly more prevalent in the genetically positive (+GT) group (21.4%) than in the negative (-GT) group (5.6%).
- The findings suggest that chondrocalcinosis is common in HPP patients, and it's important to consider genetic factors when diagnosing related conditions.
Strategies to build stronger bones in Indian children: Challenges for implementation.
Indian J Med Res
October 2024
Department of Endocrinology, CEDAR Superspeciality Healthcare, Dwarka, New Delhi, India.
Background & objectives Globally, vitamin D deficiency has been incriminated in poor bone health and growth retardation in children, impaired adult musculoskeletal health (classically described), increased risk of cardiovascular events, immune dysfunction, neurologic disorders, insulin resistance and its multiple sequelae, polycystic ovary syndrome (PCOS) and certain cancers. This review intends to holistically highlight the burden of vitamin D deficiency among children in India, the public health importance, and potential therapeutic and preventive options, utilizing the concept of implementation research. Methods A systematic search was carried out on PubMed, Embase, China National Knowledge Infrastructure (CNKI) and Cochrane database, clinicaltrials.
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