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Decreased telomerase activity and shortened telomere length in infants whose mothers have gestational diabetes mellitus and increased severity of telomere shortening in male infants.
Front Endocrinol (Lausanne)
December 2024
Department of Obstetrics and Gynecology, Hefei Maternal and Child Health Hospital, Hefei, China.
Objective: Gestational diabetes mellitus (GDM) is a common complication during pregnancy and increases the risk of metabolic diseases in offspring. We hypothesize that the poor intrauterine environment in pregnant women with GDM may lead to chromosomal DNA damage and telomere damage in umbilical cord blood cells, providing evidence of an association between intrauterine programming and increased long-term metabolic disease risk in offspring.
Methods: We measured telomere length (TL), serum telomerase (TE) activity, and oxidative stress markers in umbilical cord blood mononuclear cells (CBMCs) from pregnant women with GDM (N=200) and healthy controls (Ctrls) (N=200) and analysed the associations of TL with demographic characteristics, biochemical indicators, and blood glucose levels.
Effect of freezing and thawing on ejaculated sperm and subsequent pregnancy and neonatal outcomes in IVF.
Front Endocrinol (Lausanne)
December 2024
Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Techniques for sperm cryopreservation have exhibited their potential in male fertility preservation. The use of frozen-thawed sperm in fertilization (IVF) cycles is widespread today. However, many studies reported that cryopreservation might have adverse effects on sperm DNA integrity, motility, and fertilization, probably due to cold shock, intra- and extracellular ice crystals, and excess reactive oxygen species (ROS).
View Article and Find Full Text PDFUntargeted metabolomics analysis of glycerophospholipid metabolism in very low birth weight infants administered multiple oil lipid emulsions.
BMC Pediatr
December 2024
Department of Intensive Care Unit, Hangzhou Women's Hospital, Hangzhou, 310016, Zhejiang, China.
Background: To compare the impact of two different lipid emulsions, specifically a soybean oil-based emulsion and a multiple oil emulsion (soybean oil, medium-chain triglycerides, olive oil, and fish oil, SMOF), on serum metabolites of very low birth weight (VLBW) infants using untargeted metabolomics analysis.
Methods: A comparative study was conducted on 25 VLBW infants hospitalized in neonatal intensive care units (NICU) of Hangzhou Women's Hospital in 2023. The infants were divided into the SMOF group (13 cases) and the soybean oil group (12 cases) based on the type of lipid emulsion used during parenteral nutrition.
Assessing five-year trend and socio-demographic determinants of caesarean section delivery in Ghana.
BMC Pregnancy Childbirth
December 2024
Fred N Binka School of Public Health, University of Health and Allied Sciences, Hohoe, Ghana.
Introduction: The rate of caesarean section (C-section) deliveries has been increasing globally, including in low- and middle-income countries like Ghana. Understanding the trends, patterns, and socio-demographic determinants of C-section deliveries is crucial for improving maternal healthcare services and reducing unnecessary surgical interventions. This study aims to assess the trend and factors associated with CS deliveries in Ghana using secondary data from the District Health Information Management System 2 (DHIMS-2) database.
View Article and Find Full Text PDFMaternal and neonatal outcomes following resuscitative hysterotomy for out of hospital cardiac arrest: a systematic review.
Resuscitation
December 2024
University Hospitals Birmingham NHS Foundation Trust, Birmingham Heartlands Hospital B9 5SS UK; Warwick Clinical Trials Unit, University of Warwick, Coventry, CV4 7AL.
Objective: To examine maternal and neonatal outcomes following Resuscitative Hysterotomy for out of hospital cardiac arrest (OHCA) and to compare with timing from cardiac arrest to delivery.
Methods: The review was registered with PROSPERO (CRD42023445064). Studies included pregnant women with out of hospital cardiac arrest and resuscitative hysterotomy performed (in any setting) during cardiac arrest.
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