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Non-Canonical TERT Activity Initiates Osteogenesis in Calcific Aortic Valve Disease.
Circ Res
January 2025
Division of Cardiology, Department of Medicine, Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, PA. (R.A.C., C.C.C., R.W., A.C., C.B., C.R., W.J.M., M.J. Bashline, A.P., A.M.P., P.B., M.J. Brown, C.S.H.).
Background: Calcific aortic valve disease is the pathological remodeling of valve leaflets. The initial steps in valve leaflet osteogenic reprogramming are not fully understood. As TERT (telomerase reverse transcriptase) overexpression primes mesenchymal stem cells to differentiate into osteoblasts, we investigated whether TERT contributes to the osteogenic reprogramming of valve interstitial cells.
View Article and Find Full Text PDFis rarely associated with neurological manifestations. This report describes a rare case of endocarditis complicated by a cerebral stroke caused by . We also briefly reviewed the neurological clinical spectrum of disease described in the literature.
View Article and Find Full Text PDFUnicuspid unicommissural aortic valves: A surgical pathology analysis.
Indian J Pathol Microbiol
January 2025
Department of Pathology (Cardiovascular and Thoracic Division), Seth GS Medical College Mumbai, Maharashtra, India.
The unicuspid unicommisural aortic valve is an uncommon congenital malformation that often manifests as stenosis with or without regurgitation in adults in their third to fifth decades of life. This report characterizes the morphological features of surgically excised unicuspid valves in adults with clinical correlation. Among the surgically excised aortic valves over a period of 10 years, the clinical data and morphological features of unicuspid aortic valves were analyzed.
View Article and Find Full Text PDFDiagnosis of bicuspid aortic valves: CT vs. TTE.
Int J Cardiovasc Imaging
December 2024
Melbourne Medical School, The University of Melbourne, Parkville, VIC, Australia.
Bicuspid aortic valfves (BAV) are a relatively common cardiac abnormality, with an associated risk of aortic stenosis, aortic regurgitation and aortopathy. First-line diagnosis is via transthoracic echocardiography (TTE), which may be impacted by valve calcification and operator variability. Electrocardiogram-gated computed tomography (CT) offers an alternative form of assessment.
View Article and Find Full Text PDFSevere acute recoil following transcatheter aortic valve replacement with a self-expanding prosthesis in a heavily calcified bicuspid aortic valve.
Future Cardiol
January 2025
Division of Interventional Cardiology, La Paz University Hospital, IdiPAZ, CIBER-CV, Madrid, 28046, Spain.
Article Synopsis
- Bicuspid aortic valve (BAV) is a common congenital heart condition affecting 0.5-2% of the population and is linked to higher incidences in patients with severe aortic stenosis and older adults undergoing surgery.
- Transcatheter aortic valve replacement (TAVR) is a new treatment option for aortic stenosis, but there's insufficient evidence to identify the best approach for patients with BAV.
- The report discusses a case of severe acute recoil after TAVR with a self-expanding prosthesis in a patient with heavily calcified BAV and reviews the implications of prosthesis underexpansion in the medium term.
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