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http://dx.doi.org/10.1051/medsci/200723121084 | DOI Listing |
Open Life Sci
December 2024
Institute of Human Genetics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 34, 50931, Cologne, Germany.
Cell polarity is crucial in neurons, characterized by distinct axonal and dendritic structures. Neurons generally have one long axon and multiple shorter dendrites, marked by specific microtubule (MT)-associated proteins, e.g.
View Article and Find Full Text PDFbioRxiv
December 2024
Department of Cell, Molecular, and Developmental Biology, University of California, Los Angeles, Los Angeles, California 90095, USA.
Cell shape is crucial to cell function, particularly in neurons. The cross-sectional diameter, also known as caliber, of axons and dendrites is an important parameter of neuron shape, best appreciated for its influence on the speed of action potential propagation. Most studies of axon caliber focus on cell-wide regulation and assume that caliber is static.
View Article and Find Full Text PDFNeurobiol Dis
January 2025
Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam and VU Medical Center, Amsterdam, the Netherlands; Department of Human Genetics, Amsterdam University Medical Center, Amsterdam, the Netherlands. Electronic address:
Mutations in the microtubule-binding motor protein kinesin 5 A (KIF5A) are implicated in several adult-onset motor neuron diseases, including Amyotrophic Lateral Sclerosis, Spastic Paraplegia Type 10 and Charcot-Marie-Tooth Disease Type 2. While KIF5 family members transport a variety of cargos along axons, the specific cargos affected by KIF5A mutations remain poorly understood. Here, we generated KIF5Anull mutant human motor neurons and analyzed the impact on axonal transport and motor neuron outgrowth and regeneration in vitro.
View Article and Find Full Text PDFimaging of dynamic sub-cellular brain structures in is key to understanding several phenomena in neuroscience. However, a trade-off between spatial resolution, speed, photodamage, and setup complexity limits its implementation. Here, we designed and built a single objective light sheet microscope, customized for imaging of adult flies and optimized for maximum resolution.
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