Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1001/archpedi.1949.02030040724002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Emergence of antibiotic-specific phenotypes during prolonged treatment of mice.
Antimicrob Agents Chemother
January 2025
Rocky Mountain Regional VA Medical Center, Aurora, Colorado, USA.
A major challenge in tuberculosis (TB) therapeutics is that antibiotic exposure leads to changes in the physiology of (), which may enable the pathogen to withstand treatment. While antibiotic-treated has been evaluated in experiments it is unclear if and how long-term treatment with diverse antibiotics with varying treatment-shortening activity (sterilizing activity) affects physiologic processes differently. Here, we used SEARCH-TB, a pathogen-targeted RNA-sequencing platform, to characterize the transcriptome in the BALB/c high-dose aerosol infection mouse model following 4 weeks of treatment with three sterilizing and three non-sterilizing antibiotics.
View Article and Find Full Text PDFIn Vitro Evaluation of Rosemary Essential Oil: GC-MS Profiling, Antibacterial Synergy, and Biofilm Inhibition.
Pharmaceuticals (Basel)
December 2024
Department of Medical Microbiology, University of Ghana Medical School, Korle Bu, Accra 00233, P.O. Box KB 4236, Ghana.
Antimicrobial resistance (AMR) has become precarious, warranting investments in antimicrobial discovery. To investigate the antibacterial activity of rosemary essential oil (REO), alone and in combination with selected conventional antibiotics. REO was subjected to antimicrobial susceptibility testing (including minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC) determination) and investigation of anti-pre-biofilm and antibiofilm activities.
View Article and Find Full Text PDFClearance of Intracellular Pathogens with Hyaluronic Acid Nanomicelles Responsive to HS and pH.
Molecules
December 2024
Engineering Laboratory of Chemical Resources Utilization in South Xinjiang, Tarim University, Alar 843300, China.
Hyaluronic acid (HA) is an acidic mucopolysaccharide of animal origin composed of repeating disaccharide units of N-acetylglucosamine and glucuronic acid. Due to its excellent biocompatibility, biodegradability, and selective affinity for CD44 receptors on cell surfaces, HA is widely employed as a drug carrier. In our study, we aimed to target subcellular bacteria by grafting cystamine onto HA scaffolds through an amide reaction, producing a linker responsive to HS and pH changes.
View Article and Find Full Text PDFTherapeutic potential of Chromolaena odorata, Vernonia amygdalina, and Cymbopogon citratus against pathogenic Bacteria.
Sci Rep
January 2025
Departmment of Microbiology and Immunology, Kampala International University, Ishaka, Uganda.
Antimicrobial resistance poses a global public health threat, compelling the search for alternative treatments, especially in resource-limited settings. The increasing ineffectiveness of traditional antibiotics has intensified the need to explore medicinal plants as viable therapeutic options. This study sought to compare the efficacy of certain medicinal plants used in Owerri, Nigeria, for treating pathogenic bacteria against traditional commercial antibiotics.
View Article and Find Full Text PDFReactivation of hidden-latent infection after doxycycline and streptomycin treatment in mice.
Antimicrob Agents Chemother
December 2024
Programa de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica.
Brucellosis has therapeutic challenges due to 3%-15% relapses/therapeutic failures (R/TF) after antibiotic treatment. Therefore, determining the antibiotic concentration in tissues, the physiopathological parameters, and the R/TF after treatment is relevant. After exploring different antibiotic quantities, we found that a combined dose of 100 µg/g of doxycycline (for 45 days) and 7.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!