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Antipseudomonal cephalosporins versus piperacillin/tazobactam or carbapenems for the definitive antibiotic treatment of Pseudomonas aeruginosa bacteraemia: new kids on the ICU block?
J Antimicrob Chemother
March 2025
Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20090 Milan, Italy.
Background: Pseudomonas aeruginosa bloodstream infections (Pa-BSIs) are still a major cause of mortality in ICUs, posing many treatment uncertainties.
Methods: This multicentre, retrospective study analysed data from 14 Italian hospitals, including all consecutive adults developing Pa-BSI in ICU during 2021-22 and treated with antibiotics for at least 48 h. The primary aim was to identify predictors of 30 day mortality using Cox regression.
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024.
J Intensive Care
March 2025
Department of Anesthesia and Intensive Care, Kyoto University Hospital, Kyoto, Japan.
The 2024 revised edition of the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock (J-SSCG 2024) is published by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine. This is the fourth revision since the first edition was published in 2012. The purpose of the guidelines is to assist healthcare providers in making appropriate decisions in the treatment of sepsis and septic shock, leading to improved patient outcomes.
View Article and Find Full Text PDFPediatric trauma and resuscitation: optimizing care in an evolving landscape.
Curr Opin Anaesthesiol
March 2025
Division of Pediatric Anesthesia, Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, California, USA.
Purpose Of Review: Penetrating firearm-related injury has increased mortality rates in children in the USA. This article summarizes trends in pediatric injury patterns, the unique coagulation system of infants, and key components of hemostatic resuscitation in children.
Recent Findings: Firearm-associated penetrating trauma increased mortality and led to higher rates of pediatric massive transfusions.
Resolution of Exercise-Induced Syncope After Stenting of the Azygos Vein in a Dog with Segmental Aplasia and Azygos Continuation of the Levopositioned Caudal Vena Cava.
Animals (Basel)
March 2025
Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3584 CM Utrecht, The Netherlands.
A 1-year-old Maltese-Poodle mixed breed dog was referred to the cardiology service because of severe exercise intolerance and daily exercise-induced syncopal episodes. Physical examination revealed no abnormalities. Echocardiography showed intermittent underfilling of the heart.
View Article and Find Full Text PDFLeft ventricular-arterial coupling and mortality in the cardiac intensive care unit.
Eur Heart J Acute Cardiovasc Care
March 2025
Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Background: Left ventricular (LV) ventricular-arterial coupling (VAC) refers to the ratio of afterload (effective arterial elastance) to contractility (end-systolic elastance) as an integrated marker of cardiac performance. We sought to determine whether the echocardiographic VAC ratio, defined using the ratio of LV end-systolic volume (LVESV) to stroke volume (SV), predicted mortality in the cardiac intensive care unit (CICU).
Methods: Mayo Clinic CICU patients from 2007 and 2018 were included.
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