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Comparison of autologous hematopoietic cell transplantation, matched sibling donor hematopoietic cell transplantation, and chemotherapy in patients with favorable- and intermediate-risk acute myeloid leukemia.
Front Immunol
January 2025
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Introduction: Hematopoietic stem cell transplantation (HSCT) and chemotherapy are considered potentially curative options for post-remission therapy in acute myeloid leukemia (AML). However, the comparative effectiveness of these approaches in favorable- and intermediate-risk AML remains unclear and requires further investigation.
Methods: In this retrospective study, 111 patients diagnosed with de novo favorable- and intermediate-risk AML, categorized according to the ELN 2022 guidelines, were investigated to compare outcomes following autologous HSCT (auto-HSCT), matched sibling donor HSCT (MSD-HSCT), and chemotherapy.
Comparing circular and flexibly-shaped scan statistics for disease clustering detection.
Front Public Health
January 2025
School of Computer Science and Technology, Zhengzhou University of Light Industry, Zhengzhou, China.
The accuracy of spatial clustering detection is crucial for public health policy development and identifying etiological clues. Circular and flexibly-shaped scan statistics are widely used for disease cluster detection, but differences in results arise mainly due to parameter sensitivity and variations in the scanning window shapes. This study aims to analyze the impact of parameter settings on the results of these methods and compare their performance in disease clustering detection.
View Article and Find Full Text PDFEvaluation of racial/ethnic disparities in surgical outcomes after rectal cancer resection: An ACS-NSQIP analysis.
Surg Pract Sci
June 2024
Division of Colorectal Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Background: Disparities exist the management of rectal cancer. We sought to evaluate short-term surgical outcomes among different racial/ethnic groups following rectal cancer resection.
Materials And Methods: National Surgical Quality Improvement Program (NSQIP) database (2016-2019) was queried.
Laparoscopic versus open loop ileostomy reversal: A systematic review and meta-analysis.
Surg Pract Sci
June 2023
Division of General Surgery, Department of Surgery, McMaster University, Hamilton, ON, Canada.
Background: Loop ileostomies (LIs) are used for temporary fecal diversion to protect downstream colorectal anastomoses. Standard operative approach for LI reversal has been through an open technique. Recently, laparoscopic LI reversal has been employed and studied.
View Article and Find Full Text PDFComparative genomics of thermosynechococcaceae and thermostichaceae: insights into codon usage bias.
Acta Biochim Pol
January 2025
School of Food and Bioengineering, Chengdu University, Chengdu, China.
Members of the families Thermosynechococcaceae and Thermostichaceae are well-known unicellular thermophilic cyanobacteria and a non-thermophilic genus was newly classified into the former. Analysis of the codon usage bias (CUB) of cyanobacterial species inhabiting different thermal and non-thermal niches will benefit the understanding of their genetic and evolutionary characteristics. Herein, the CUB and codon context patterns of protein-coding genes were systematically analyzed and compared between members of the two families.
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