AI Article Synopsis
- The study examined tumor occurrence in 92 male and 182 female Sprague-Dawley rats, finding an overall tumor incidence of 85.9% in males and 97.8% in females.
- The most common tumors observed were mammary tumors in females at 84.6%, while in males, adrenal tumors were most prevalent at 53.2%.
- Female rats had a shorter lifespan (719 days) compared to males (752 days), largely due to the high rate of mammary tumors developing between 16 to 18 months.
Article Abstract
The longevity and incidence of spontaneous tumors was investigated in 92 male and 182 female rats of the Sprague-Dawley (SD) derived stock Him: OFA. The overall tumour incidence was 85.9% in males and 97.8% in females with 32 different types of tumors in males and 30 in females. The most frequent neoplasms were mammary tumours in females with 84.6% incidence, followed in this sex by adrenal (36.8%), pituitary (32.9%) and thyroid neoplasms (10.9%). The incidence of all neoplasms in female genital tract was 12.6%. In male rats tumours of the adrenals have the highest incidence (53.2%, most of them cortical) followed by pituitary tumours (31.5%) and neoplasm of the mesenteric lymph nodes (14.1%, which is uncommonly high compared with other Sprague-Dawley stocks). All other tumours are below 10% incidence. The mean lifespan of females is with 719 +/- 142 d shorter than that of males with 752 +/- 108 d because of the high incidence of mammary tumours between 16 to 18 months of age.
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