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Dissecting regional variability in Pyrazinamide prescribing practices for tuberculosis treatment in Japan.
J Clin Tuberc Other Mycobact Dis
December 2024
Department of Pulmonology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan.
Article Synopsis
- The study examined how pyrazinamide (PZA) prescribing varies across Japan's 47 prefectures and what factors influence this variation.
- The analysis showed that there was a significant difference in PZA prescriptions, linked positively to tuberculosis (TB) incidence and the number of respiratory specialists, but negatively to the proportion of elderly TB patients.
- It concluded that addressing regional differences in PZA prescriptions is essential for improving TB management, particularly by increasing respiratory specialist availability.
Backgrounds: Scrub Typhus is a re-emerging illness with considerable morbidity and mortality and affected children have nonspecific sign symptoms. This study was conducted to find out the risk factors, clinical characteristics and laboratory profile and treatment outcome of scrub typhus among the children admitted in tertiary level pediatric hospital for febrile illness.
Methods: A case control study was conducted among hospitalized children with acute febrile illness in a government pediatric referral hospital of central Nepal for two years (2021 to Sept 2023), who were tested using Scrub Typhus Antibody Rapid Test Kit.
Spatiotemporal patterns and socioeconomic determinants of pulmonary tuberculosis in Dongguan city, China, during 2011-2020: an ecological study.
BMJ Open
September 2024
Department of Prevention and Health Care, The Sixth People's Hospital of Dongguan City, Dongguan, China
Objective: Pulmonary tuberculosis (PTB) is a critical challenge worldwide, particularly in China. This study aimed to explore the spatiotemporal transmission patterns and socioeconomic factors of PTB in Dongguan city, China.
Methods/design: An ecological study based on the reported new PTB cases between 2011 and 2020 was conducted in Dongguan city, China.
The impact of diabetes mellitus on blood-tissue barrier regulation and vascular complications: Is the lung different from other organs?
Tissue Barriers
July 2024
Clinical and Experimental Therapeutics, University of Georgia, Augusta, GA, USA.
Diabetes Mellitus presents a formidable challenge as one of the most prevalent and complex chronic diseases, exerting significant strain on both patients and the world economy. It is recognized as a common comorbidity among severely ill individuals, often leading to a myriad of micro- and macro-vascular complications. Despite extensive research dissecting the pathophysiology and molecular mechanisms underlying vascular complications of diabetes, relatively little attention has been paid to potential lung-related complications.
View Article and Find Full Text PDFAnalysis of the performance of health services in a group of vulnerable municipalities.
Cien Saude Colet
July 2024
Escola Nacional de Saúde Pública Sérgio Arouca, Fiocruz. Rio de Janeiro RJ Brasil.
This work was a descriptive study that analyzed the performance of health services in 112 municipalities (g100) characterized by more than 80,000 inhabitants, low public revenue, and socioeconomic vulnerability. Based on the Projeto de Avaliação de Desempenho do Sistema de Saúde, 31 indicators of funding, resources, access, effectiveness, acceptability, and appropriateness were selected for the period of 2017-2020, and were compared to the variations of each year's indicators year on year. In 2020, an increase in funding, especially SUS transfers (31.
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