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Country-specific key lifestyle factors and health outcomes for resource allocation in the general population: a network analysis across 29 countries.
J Glob Health
January 2025
Medical-surgical Nursing Department, Faculty of Nursing, Cairo University, Cairo, Egypt.
Background: We aimed to identify the central lifestyle, the most impactful among lifestyle factor clusters; the central health outcome, the most impactful among health outcome clusters; and the bridge lifestyle, the most strongly connected to health outcome clusters, across 29 countries to optimise resource allocation for local holistic health improvements.
Methods: From July 2020 to August 2021, we surveyed 16 461 adults across 29 countries who self-reported changes in 18 lifestyle factors and 13 health outcomes due to the pandemic. Three networks were generated by network analysis for each country: lifestyle, health outcome, and bridge networks.
Household water security is a mediator of household food security in a nationally representative sample of Mexico.
Public Health Nutr
January 2025
Department of Anthropology and Institute for Policy Research, Northwestern University, Evanston, IL, USA.
Objective: Explore the relationship between water insecurity and food security and their covariates in Mexican households.
Design: A cross-sectional study with nationally representative data from the National Health and Nutrition Survey-Continuous 2021 (in Spanish, ENSANUT-Continua 2021), collected data from 12,619 households.
Setting: Water insecurity was measured using the Household Water Insecurity Experiences (HWISE) Scale in Spanish and adapted to the Mexican context.
Evolving trends in novel sleep tracking and sleep testing technology publications between 2020-2022.
J Clin Sleep Med
January 2025
Indiana University School of Medicine, Indianapolis, Indiana.
Study Objectives: To update sleep medicine providers regarding (1) published research on the uses and performance of novel sleep tracking and testing technologies (2) the use of artificial intelligence to acquire and process sleep data and (3) research trends and gaps regarding the development and/or evaluation of these technologies.
Methods: Medline and Embase electronic databases were searched for studies utilizing screening and diagnostic sleep technologies, published between 2020 and 2022 in journals focusing on human sleep. Studies' quality was determined based on the Study Design criteria of The Oxford Centre for Evidence-Based Medicine Levels of Evidence.
Exploration of the Fasting Hypoglycemic Mechanism of Casein Hydrolysate Enriched with Glu/Gln and Glu/Gln-Containing Peptides in db/db Diabetic-like Mice Using Multiomics Analysis.
J Agric Food Chem
January 2025
School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.
The fasting hypoglycemic effect of casein hydrolysate (CH) was investigated in db/db diabetic-like mice using a multiomics integrated analysis of peptidome, transcriptome, and metabolome. Results showed that the oral administration of CH at a dose of 600 mg/kg/day for 4 weeks reduced the fasting blood glucose levels by 14.73 ± 9.
View Article and Find Full Text PDFElucidating the structure and function of a membrane-active plant protein domain using in silico mutagenesis.
Biochim Biophys Acta Biomembr
January 2025
Land and Food Systems, University of British Columbia, Vancouver, Canada; Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, Canada. Electronic address:
The Solanum tuberosum (common potato) plant specific insert (StPSI) is an antimicrobial protein domain that exhibits membrane-disrupting and membrane-fusing activity upon dimerization at acidic pH, activity proposed to involve electrostatic attraction and membrane anchoring mediated by specific positively-charged and conserved tryptophan residues, respectively. This study is the first to employ an in silico mutagenesis approach to clarify the structure-function relationship of a plant specific insert (PSI), where ten rationally-mutated StPSI variants were investigated using all-atom and coarse-grained molecular dynamics. The tryptophan (W) residue at position 18 (W18) of wild-type StPSI was predicted to confer structural flexibility to the dimer and mediate a partial separation of the assembled monomers upon bilayer contact, while residues including W77 and the lysine (K) residue at position 83 (K83) were predicted to stabilize secondary structure and influence association with the model membrane.
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