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Association between the triglyceride-glucose index and its combined obesity indicators and the risk of hypertension in middle-aged and older Chinese adults: A nationwide cross-sectional study.
PLoS One
January 2025
Department of Endocrinology and Metabolism, The Third People's Hospital of Jingdezhen, Jingdezhen, China.
Objective: This study aimed to explore the association between the triglyceride-Glucose Index (TyG) and its combination with obesity indicators in relation to the risk of hypertension among middle-aged and elderly individuals in China.
Methods: A total of 9,248 participants aged 45 and above were selected from the 2015 China Health and Retirement Longitudinal Study. Data on basic demographics, behavioral habits, medical history, physical examination results, and blood indicators were collected.
Discovery of 3-amide-pyrimidine-based derivatives as potential fms-like tyrosine receptor kinase 3 (FLT3) inhibitors for treating acute myelogenous leukemia.
Bioorg Med Chem Lett
March 2025
Department of Medicinal Chemistry and Pharmaceutical Analysis, School of Pharmacy, Fourth Military Medical University, Xi'an, Shaanxi 710032, China. Electronic address:
Article Synopsis
- FLT3-ITD and TKD mutants are key drivers in acute myeloid leukemia (AML), making FLT3 a promising target for new treatments.
- To identify next-generation FLT3 inhibitors, researchers modified G-749 and found that a derivative named MY-10 showed strong and selective inhibition against FLT3-ITD and FLT3-D835Y mutants.
- MY-10 was effective in blocking cell cycle progression, inducing apoptosis, and reducing harmful reactive oxygen species, while not affecting c-KIT kinase, suggesting its potential as a targeted ACML therapy.
Compact Arterial Monitoring Device Use in Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA): A Simple Validation Study in Swine.
Cureus
October 2024
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, USA.
Article Synopsis
- - Hemorrhage is the main cause of preventable death in trauma situations, leading to military and civilian advancements in medical practices, particularly through the use of tourniquets to manage extremity bleeding and save lives.
- - While tourniquets have significantly decreased deaths from bleeding in military settings, noncompressible hemorrhage still poses a major risk, especially before patients receive definitive medical care.
- - The study explores using a small, disposable pressure monitor during resuscitative endovascular balloon occlusion of the aorta (REBOA) to enhance blood pressure monitoring, facilitate better resuscitation practices, and reduce the need for blood products in extreme environments.
Pathologic Response of Phase III Study: Perioperative Camrelizumab Plus Rivoceranib and Chemotherapy Versus Chemotherapy for Locally Advanced Gastric Cancer (DRAGON IV/CAP 05).
J Clin Oncol
February 2025
Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Article Synopsis
- - This phase III trial tested the effectiveness and safety of combining camrelizumab, a type of cancer immunotherapy, with low-dose rivoceranib and a chemotherapy regimen (SOX) in patients with advanced gastric or gastroesophageal junction adenocarcinoma.
- - Patients were randomly assigned to receive either the combination treatment (SOXRC), a different regimen with higher rivoceranib dose (SOXR), or just the chemotherapy (SOX). Only SOXRC and SOX groups are reported here, with strong results supporting the efficacy of SOXRC.
- - The findings showed that the SOXRC group had a significantly higher rate of pathologic complete response (18.3% vs. 5
Perspectives of work readiness among Australian health students trained during the COVID-19 pandemic.
BMC Med Educ
September 2024
Department of Rural Health, The University of Melbourne, 49 Graham St, Shepparton, VIC, 3630, Australia.
Background: To explore perspectives of work readiness, including readiness to work rurally, among health students trained in Australia during the COVID-19 pandemic.
Methods: Participants were allied health, medicine, and nursing students in the later years of their degree (third, fourth or final year of an undergraduate entry to practice degree, or second year of postgraduate entry to practice degree), where training is clinically immersive. These students had completed a University Department of Rural Health facilitated rural and remote placement between January 2021 and October 2022.
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