Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Symmetrical Drug-Related Intertriginous and Flexural Exanthema With Amoxicillin: Presenting a Flare-Up Phenomenon.
Cureus
November 2024
Allergy Department, Hospital General Universitario Gregorio Marañón, Madrid, ESP.
This case report describes a 40-year-old male patient who developed symmetrical drug-related intertriginous and flexural exanthema after taking amoxicillin. Initial allergy testing showed negative intradermal tests, but subsequent drug provocation tests with amoxicillin and penicillin were positive, indicating cross-reactivity between these β-lactam antibiotics. Notably, following the final provocation test, the intradermal test with penicillin turned positive, demonstrating a flare-up phenomenon.
View Article and Find Full Text PDFAssessment of the Safety of Alternative Antibiotics in Children with Confirmed Beta-Lactam Antibiotic Allergy.
Int Arch Allergy Immunol
November 2024
Department of Pediatric Allergy/Immunology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkey.
Introduction: Beta-lactam antibiotics (BLAs) are the most common cause of drug hypersensitivity reactions in children, and it is important to find safe alternative antibiotics for these children. This study evaluates the selection, safety to alternative antibiotics in patients with confirmed BLA allergies based on diagnostic tests.
Methods: At the Pediatric Immunology and Allergy Clinic of Ankara Bilkent City Hospital, a retrospective evaluation of diagnostic tests (including skin prick, intradermal, and drug provocation tests) was conducted to identify alternative antibiotics for patients with confirmed BLA.
Stability of Antibiotics for Use in the Testing of Immediate Drug Allergy Reactions.
J Allergy Clin Immunol Pract
November 2024
Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Article Synopsis
- Limited information exists about the stability of penicillin-based antibiotics for skin testing, prompting a study on 16 parenteral antibiotics to evaluate their physicochemical stability and provide guidelines for clinicians.
- Most antibiotics showed good stability for 2 to 7 days, with amoxicillin/clavulanic acid being a notable exception, dropping below acceptable levels by day 2.
- The research included specific tests for chemical and physical stability, revealing that while many antibiotics maintained acceptable performance, some experienced significant color changes and pH drops over time.
Diagnosis and clinical management of drug allergies in obstetrics and gynecology: an expert review.
Am J Obstet Gynecol
October 2024
Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY; Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT. Electronic address:
Article Synopsis
- Drug allergies, especially to antibiotics like penicillin, are common in obstetrics and gynecology, affecting about 10% of the US population and complicating treatment options for infections.
- Using alternative antibiotics due to reported allergies can lead to significant complications such as increased surgery rates, longer hospital stays, and higher healthcare costs, plus a risk of severe reactions like anaphylaxis.
- More than 90% of those who claim a penicillin allergy can actually tolerate it, so allergy evaluations—including patient histories and tests—are recommended to ensure appropriate use of first-line antibiotics during pregnancy and beyond.
Reliability and validation of an electronic penicillin allergy risk-assessment tool in a pregnant population.
Allergy Asthma Clin Immunol
October 2024
Division of Allergy and Immunology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Article Synopsis
- Penicillin allergies often lead to unnecessary treatment delays, as many reported allergies are not true allergies; efficient tools are needed to identify low-risk patients for safe de-labeling.
- The FIRSTLINE electronic decision support tool was implemented to help clinicians assess and stratify penicillin allergy risk among pregnant women in Vancouver, with a focus on its reliability compared to allergist evaluations and other tools like JAMA and PENFAST.
- Results showed that 97.2% of 181 patients were not allergic, and FIRSTLINE effectively identified a high percentage of low-risk patients, emphasizing the value of clinical algorithms in improving patient care.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!