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Topical frankincense treatment for frostbite based on microcirculation improvements.
J Ethnopharmacol
January 2025
Lab of Hepatopharmacology and Ethnopharmacology, School of Pharmaceutical Sciences, South-central Minzu University, No. 182, Minyuan Road, Wuhan 430074, China. Electronic address:
Article Synopsis
- Frankincense is a traditional Chinese medicine that helps improve blood flow and can be used to treat skin injuries like frostbite.
- The study looked at how frankincense oil extract (FOE) helps frostbite wounds heal faster by increasing temperature and improving skin structure.
- Results showed that FOE not only helped warm and heal the skin but also reduced inflammation and stopped cell damage, making it a promising treatment for frostbite.
Inhibition of AIM2 expression enhance treatment effect of osimertinib in treatment of glioma.
Folia Neuropathol
August 2024
Clinic of Xiangjiang Road Primary School, Tianjin, China.
Article Synopsis
- Glioma is a prevalent brain tumor accounting for 80% of cases and is challenging to treat, particularly with the limited options for effective therapy using EGFR tyrosine kinase inhibitors (TKIs) like osimertinib, which targets specific mutations.
- Osimertinib shows promise against EGFR mutations but faces complications due to the secretion of pro-cancer cytokines that may lead to treatment resistance, especially influenced by the protein AIM2.
- Research indicates that inhibiting AIM2 could enhance the therapeutic effects of EGFR-TKIs like osimertinib, potentially by regulating inflammatory gene expression and improving patient outcomes.
Tat-CIRP Peptide Facilitates Frozen Wound Healing by Ameliorating Inflammation and Promoting Angiogenesis.
J Inflamm Res
April 2024
Department of Hypoxic Biomedicine, Institute of Special Environmental Medicine and Coinnovation Center of Neuroregeneration, Nantong University, Nantong, 226019, People's Republic of China.
Background: Frostbite is a chemia resulting from cold-induced skin damage. The process of frostbite is often accompanied by inflammation, and the therapeutic strategies focusing on anti-inflammation are the main direction to data. Tat-CIRP is a 15 amino acid peptide containing HIV protein and cold-inducible RNA-binding protein (CIRP), which is believed to compete with endogenous CIRP for myeloid differentiation 2 (MD2) binding.
View Article and Find Full Text PDFExtracellular Vesicles Derived from Adipose-Derived Stem Cells Facilitate Frostbite Wound Healing By Regulating SOCS3 Expression.
Curr Stem Cell Res Ther
May 2023
Department of General Surgery, Jilin University Second Hospital, Changchun, China.
Background: Though adipose-derived stem cells (ADSCs) have potential applications for the repair and regeneration of damaged tissues, limited studies have defined the function of ADSCs on dermal fibroblasts. Our RNA-seq sequencing identified differentially expressed SOCS3 in frostbite injury.
Objective: In the current study, we aim to examine the hypothesis that extracellular vesicles derived from adipose-derived mesenchymal stem cells (ADSCs-EVs) may modulate SOCS3/TGF-β1 signaling in wound healing of frostbite injury.
Hypoxia-induced nuclear translocation of β-catenin in the healing process of frostbite.
Biochim Biophys Acta Mol Basis Dis
June 2022
Forensic Medicine Laboratory, Department of Oncology-Pathology, Karolinska Institute, Sweden.
Frostbite occurs when the skin is exposed to localized low temperatures. The main causes of frostbite are thought to be direct cell injury due to freezing of cells and tissue ischemia due to abnormal blood circulation. However, the molecular mechanism of frostbite has not been elucidated.
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