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Advancements in microalgal biomass conversion for rubber composite applications.
Sci Rep
January 2025
Hydrobiology Lab, Water Pollution Research Department, National Research Centre, Dokki, Giza, 12622, Egypt.
Carbon black (CB) as rubber reinforcement has raised environmental concerns regarding this traditional petroleum-based filler, which is less susceptible to biodegradability. Although it has great reinforcing properties, the production technique is no longer sustainable, and its cost increases regularly. For these reasons, it is wise to look for sustainable replacement materials.
View Article and Find Full Text PDFAssociations between volatile organic compounds exposure and multiple oxidative damage biomarkers: Method development, human exposure, and application for e-waste pollution prediction.
Sci Total Environ
December 2024
State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment, South China Institute of Environmental Sciences, Ministry of Ecology and Environment, Guangzhou 510655, PR China. Electronic address:
Atmospheric monitoring studies reveal substantial health risks from exposure to volatile organic compounds (VOCs) for workers and nearby children in e-waste recycling areas (ERA), yet internal exposure risks are seldom examined. To address this, we developed a method to simultaneously analyze 12 urinary VOC metabolites (mVOCs) and oxidative damage biomarkers (ODBs) in workers and children from ERA and general adults from control areas using ultrahigh performance liquid chromatography coupled with quadrupole/orbitrap high-resolution mass spectrometry (UPLC-Orbitrap-HRMS). The results showed that e-waste workers exhibited significantly higher levels of VOC exposure and ODBs than e-waste children and control adults.
View Article and Find Full Text PDFCatalytic and post-translational maturation roles of a conserved active site serine residue in nitrile hydratases.
J Inorg Biochem
January 2025
Department of Chemistry, Colorado School of Mines, Golden, CO 80401, USA. Electronic address:
A highly conserved second-sphere active site αSer residue in nitrile hydratase (NHase), that forms a hydrogen bond with the axial metal-bound water molecule, was mutated to Ala, Asp, and Thr, in the Co-type NHase from Pseudonocardia thermophila JCM 3095 (PtNHase) and to Ala and Thr in the Fe-type NHase from Rhodococcus equi TG328-2 (ReNHase). All five mutants were successfully purified; metal analysis via ICP-AES indicated that all three Co-type PtNHase mutants were in their apo-form while the Fe-type αSer117Ala and αSer117Thr mutants contained 85 and 50 % of their active site Fe(III) ions, respectively. The k values obtained for the PtNHase mutant enzymes were between 0.
View Article and Find Full Text PDFElevated Urinary Levels of Fungal and Environmental Toxins in Patients with Pancreatic Ductal Adenocarcinoma.
J Gastrointest Cancer
October 2024
Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL, USA.
Background: Risk factors for pancreatic ductal adenocarcinoma (PDAC) include tobacco/alcohol abuse, genetic predisposition, insulin resistance, and pancreatic cysts. Despite these well-established risk factors and the screening of high-risk individuals, some people still develop PDAC. This study aims to explore a potential risk factor for PDAC by investigating the association between fungal toxins (FT) and environmental toxins (ET) and the disease.
View Article and Find Full Text PDFIdentification of Specific Hemoglobin Adduct Patterns in Users of Different Tobacco/nicotine Products by Nontargeted GC-MS/MS Analysis.
Chem Res Toxicol
November 2024
ABF, Analytisch-Biologisches Forschungslabor GmbH, Semmelweisstr. 5, Planegg 82152, Germany.
Tobacco smoke contains several electrophilic constituents which are capable of forming adducts with nucleophilic sites in DNA and proteins like hemoglobin (Hb) and albumin. New nicotine and tobacco products are discussed as less harmful forms of tobacco use compared to smoking combustible cigarettes (CC) due to reduced exposure to harmful constituents. Hence, the adduct profile in users of various tobacco/nicotine products is expected to differ characteristically.
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