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Alcohol drinking leads to sex-dependent differentiation of T cells.
Eur J Trauma Emerg Surg
January 2025
Department of Trauma Surgery and Orthopedics, Goethe University, University Hospital, Frankfurt, Germany.
Objective: Global per capita alcohol consumption is increasing, posing significant socioeconomic and medical challenges also due to alcohol-related traumatic injuries but also its biological effects. Trauma as a leading cause of death in young adults, is often associated with an increased risk of complications, such as sepsis and multiple organ failure, due to immunological imbalances. Regulatory T cells play a crucial role in maintaining immune homeostasis by regulating the inflammatory response.
View Article and Find Full Text PDFEngineered enhances bone regeneration via immunoregulation and anti-Infection.
Bioact Mater
April 2025
Department of Orthopedic Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, PR China.
Chronic osteomyelitis caused by implant infections is a common complication following orthopedic surgery. Preventing bacterial infection and simultaneously improving bone regeneration are the key for osteomyelitis. Current treatments include systemic antibiotics and multiple surgical interventions, but the strategies available for treatment are limited.
View Article and Find Full Text PDFMultidisciplinary Management of Complex Trauma and Burn Injuries: A Case Series of Challenging Clinical Scenarios.
Cureus
December 2024
General Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.
Trauma and burn injuries often present with multiple complications, necessitating a coordinated, multidisciplinary approach to management. This case series reviews the outcomes and challenges of treating high-risk trauma and burn patients, with a focus on complex polytrauma, alcohol withdrawal, high-voltage electrical injuries, and lightning strikes. Each case underscores the importance of early intervention, multidisciplinary team involvement, and individualized treatment protocols for improving patient outcomes in critically injured burn victims.
View Article and Find Full Text PDFAcute respiratory distress syndrome (ARDS): from mechanistic insights to therapeutic strategies.
MedComm (2020)
February 2025
Department of Emergency Ruijin Hospital, Shanghai Jiaotong University School of Medicine Shanghai China.
Acute respiratory distress syndrome (ARDS) is a clinical syndrome of acute hypoxic respiratory failure caused by diffuse lung inflammation and edema. ARDS can be precipitated by intrapulmonary factors or extrapulmonary factors, which can lead to severe hypoxemia. Patients suffering from ARDS have high mortality rates, including a 28-day mortality rate of 34.
View Article and Find Full Text PDFExploring the Impact of Sports Participation on Social Capital and Health-related Factors in Individuals with Spinal Cord Injury: A Cross-sectional Study.
Phys Ther Res
October 2024
Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Objective: This study examined the impact of sports participation on the health status of individuals with spinal cord injuries (SCI), with emphasis on the role of health-related social capital (HRSC).
Methods: This study included 65 individuals with SCI (42 who participated in sports and 23 who did not). The following information was obtained from the participants through an online questionnaire: their basic information, information regarding activities of daily life independence, physical activity, mental health, lifestyle, insomnia, and social capital.
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